{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T06:59:35Z","timestamp":1775890775228,"version":"3.50.1"},"reference-count":80,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Annona<\/jats:italic>\n                    species (Annonaceae family) are valued for their nutritional and medicinal importance, especially in traditional medicine. This study investigated the phenolic profiles of the Angolan\n                    <jats:italic>Annona muricata<\/jats:italic>\n                    ,\n                    <jats:italic>Annona squamosa<\/jats:italic>\n                    , and\n                    <jats:italic>Annona senegalensis<\/jats:italic>\n                    leaves, stem barks, and seeds hydroethanolic, infusion, and decoction extracts, also evaluating their antioxidant, antimalarial, and antimicrobial potential. Our results showed a vibrant phenolic profile in all the studied species, with\n                    <jats:italic>A. muricata<\/jats:italic>\n                    standing out with 44 compounds identified, with leaves containing the highest concentration of total phenolic compounds, particularly in\n                    <jats:italic>A. senegalensis<\/jats:italic>\n                    . Procyanidin trimer was the primary compound found in\n                    <jats:italic>A. muricata<\/jats:italic>\n                    leaf and stem bark hydroethanolic extract and infusion preparation, while in\n                    <jats:italic>A. squamosa<\/jats:italic>\n                    , epigallocatechin and catechin prevail. In\n                    <jats:italic>A. senegalensis<\/jats:italic>\n                    , quercetin\u20103\u2010\n                    <jats:italic>O<\/jats:italic>\n                    \u2010rutinoside was primarily detected in the leaves and isorhamnetin\u20103\u2010\n                    <jats:italic>O<\/jats:italic>\n                    \u2010rutinoside in the stem barks. Extracts from\n                    <jats:italic>A. senegalensis<\/jats:italic>\n                    performed a higher antioxidant capacity, while the hydroethanolic extract of\n                    <jats:italic>A. muricata<\/jats:italic>\n                    displayed better antimalarial activity.\n                    <jats:italic>A. senegalensis<\/jats:italic>\n                    showed the highest antioxidant activity, while\n                    <jats:italic>A. muricata<\/jats:italic>\n                    extract was most effective against malaria; all extracts displayed antibacterial effects. These results reveal the remarkable phenolic richness and bioactive potential of the studied species, supporting their traditional medicinal uses and emphasizing the pharmaceutical and industrial relevance of\n                    <jats:italic>Annona<\/jats:italic>\n                    species.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202503294","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T18:36:12Z","timestamp":1765391772000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Phenolic Profile and Bioactive Prospects of Wild\n                    <i>Annona<\/i>\n                    Species From Angola"],"prefix":"10.1002","volume":"23","author":[{"given":"Josefa","family":"Rangel","sequence":"first","affiliation":[{"name":"Linking Landscape, Environment, Agriculture and Food Research Center (LEAF), Associated Laboratory TERRA, Instituto Superior de Agronomia (ISA) Universidade de Lisboa  Lisboa Portugal"},{"name":"Centro de Bot\u00e2nica Universidade Agostinho Neto  Luanda Angola"},{"name":"CIMO, LA SusTEC Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia  Bragan\u00e7a Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c2ngela","family":"Liberal","sequence":"additional","affiliation":[{"name":"CIMO, LA SusTEC Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia  Bragan\u00e7a Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiane C.","family":"Finimundy","sequence":"additional","affiliation":[{"name":"CIMO, LA SusTEC Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia  Bragan\u00e7a Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T\u00e2nia S. P.","family":"Pires","sequence":"additional","affiliation":[{"name":"CIMO, LA SusTEC Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia  Bragan\u00e7a Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1675-4504","authenticated-orcid":false,"given":"Pedro","family":"Cravo","sequence":"additional","affiliation":[{"name":"Global Global Health and Tropical Medicine (GHTM) Associate Laboratory in Translation and Innovation Towards Global Health, (LA\u2010REAL) Instituto de Higiene e Medicina Tropical, (IHMT), Universidade NOVA De Lisboa (UNL)  Lisboa Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Concei\u00e7\u00e3o Silva","sequence":"additional","affiliation":[{"name":"Global Global Health and Tropical Medicine (GHTM) Associate Laboratory in Translation and Innovation Towards Global Health, (LA\u2010REAL) Instituto de Higiene e Medicina Tropical, (IHMT), Universidade NOVA De Lisboa (UNL)  Lisboa Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo Capatti","family":"Cassiano","sequence":"additional","affiliation":[{"name":"Global Global Health and Tropical Medicine (GHTM) Associate Laboratory in Translation and Innovation Towards Global Health, (LA\u2010REAL) Instituto de Higiene e Medicina Tropical, (IHMT), Universidade NOVA De Lisboa (UNL)  Lisboa Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9050-5189","authenticated-orcid":false,"given":"Lillian","family":"Barros","sequence":"additional","affiliation":[{"name":"CIMO, LA SusTEC Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia  Bragan\u00e7a Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9373-6302","authenticated-orcid":false,"given":"Maria M.","family":"Romeiras","sequence":"additional","affiliation":[{"name":"Linking Landscape, Environment, Agriculture and Food Research Center (LEAF), Associated Laboratory TERRA, Instituto Superior de Agronomia (ISA) Universidade de Lisboa  Lisboa Portugal"},{"name":"Centre For Ecology Evolution and Environmental Changes (cE3c) &amp; CHANGE\u2014 Global Change and Sustainability Institute Faculdade de Ci\u00eancias, Universidade De Lisboa  Lisboa Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0157-9873","authenticated-orcid":false,"given":"\u00c2ngela","family":"Fernandes","sequence":"additional","affiliation":[{"name":"CIMO, LA SusTEC Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia  Bragan\u00e7a Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13002\u2010022\u201000512\u20100"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2016.02.032"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-18923-4"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.70283"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.6736"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.118511"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2024.139048"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/tax.13260"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppp3.10321"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2020.109775"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/biolinnean\/blaf114"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arabjc.2016.01.004"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-30182-8_5"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/2515690x231165104"},{"key":"e_1_2_9_16_1","first-page":"167","article-title":"Basal Cell Carcinoma: Pathogenesis, Epidemiology, Clinical Features, Diagnosis, Histopathology, and Management","volume":"88","author":"Marzuka A. 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