{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T07:00:39Z","timestamp":1775890839779,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Tuberculosis (TB) continues to pose a major global health challenge, particularly due to the rise of multidrug\u2010resistant strains, necessitating the search for novel chemotypes with improved efficacy. In this work, a series of furan\u2010based triazole\u2010acrylamide hybrids\n                    <jats:bold>(8a<\/jats:bold>\n                    \u2013\n                    <jats:bold>8j)<\/jats:bold>\n                    were designed and synthesized via a three\u2010step sequence involving amidation, aryl azide preparation, and Cu(I)\u2010catalyzed azide\u2013alkyne cycloaddition (CuAAC). The structures of the synthesized compounds were confirmed through spectroscopic analyses, including attached proton test (APT) NMR. Biological screening against\n                    <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                    H37Rv revealed promising activity, with the 4\u2010bromo derivative (\n                    <jats:bold>8e<\/jats:bold>\n                    ) exhibiting the highest potency (minimum inhibitory concentration [MIC]\u00a0=\u00a01.25\u00a0\u00b5g\u00a0mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    ), followed by 4\u2010CF\n                    <jats:sub>3<\/jats:sub>\n                    (\n                    <jats:bold>8f<\/jats:bold>\n                    , 3.12\u00a0\u00b5g\u00a0mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) and 4\u2010F (\n                    <jats:bold>8g<\/jats:bold>\n                    , 6.25\u00a0\u00b5g\u00a0mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    ). Structure\u2013activity relationship analysis highlighted the beneficial role of electron\u2010withdrawing and polarizable substituents at the\n                    <jats:italic>para<\/jats:italic>\n                    position of the phenyl ring. Molecular docking studies demonstrated strong binding affinities (up to \u22129.6\u00a0kcal\u00a0mol\n                    <jats:sup>\u22121<\/jats:sup>\n                    for\n                    <jats:bold>8e<\/jats:bold>\n                    ), correlating well with experimental MIC values, whereas density functional theory (DFT) analyses confirmed favorable electronic properties, including a narrow HOMO\u2013LUMO gap and high softness for\n                    <jats:bold>8e<\/jats:bold>\n                    , supporting its superior bioactivity.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202503298","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T12:44:29Z","timestamp":1772973869000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis and Anti\u2010Tubercular Activity of Novel Furan\u2010Based Triazole\u2010Acrylamide Hybrids: Experimental and Computational Insights"],"prefix":"10.1002","volume":"23","author":[{"given":"Hiren","family":"Dedaniya","sequence":"first","affiliation":[{"name":"Department of Chemistry School of Science RK University  Rajkot Gujarat India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jignesh","family":"Kamdar","sequence":"additional","affiliation":[{"name":"Department of Microbiology School of Science RK University  Rajkot Gujarat India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5041-1228","authenticated-orcid":false,"given":"Khushal","family":"Kapadiya","sequence":"additional","affiliation":[{"name":"Department of Chemistry School of Science RK University  Rajkot Gujarat 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