{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T01:22:04Z","timestamp":1789435324874,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In this study, new thiazole derivatives containing hydrazone and bromothiophene moieties were synthesized, and their structures were elucidated using\n                    <jats:sup>1<\/jats:sup>\n                    H NMR,\n                    <jats:sup>1<\/jats:sup>\n                    <jats:sup>3<\/jats:sup>\n                    C NMR, and HRMS. Antimicrobial and antioxidant tests were conducted to assess their biological activities. In the antimicrobial section, compound\n                    <jats:bold>2e<\/jats:bold>\n                    showed moderate activity on Gram\u2010positive (\n                    <jats:italic>Bacillus subtilis<\/jats:italic>\n                    and\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    ), Gram\u2010negative (\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    and\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    ), and fungal strains (\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    and\n                    <jats:italic>Candida krusei<\/jats:italic>\n                    ) with minimum inhibitory concentration (MIC) values of 125, 250, and 500\u00a0\u00b5g\/mL, respectively. Furthermore, according to the agar diffusion assay, compounds\n                    <jats:bold>2a<\/jats:bold>\n                    and\n                    <jats:bold>2e<\/jats:bold>\n                    showed the most significant antibacterial activity. Their antioxidant properties were investigated by the DPPH radical scavenging method, and among them, compound\n                    <jats:bold>2b<\/jats:bold>\n                    showed the highest activity with an IC\n                    <jats:sub>50<\/jats:sub>\n                    value of 29.16\u00a0\u00b1\u00a00.009\u00a0\u00b5M. Compound\n                    <jats:bold>2e<\/jats:bold>\n                    showed activity close to that of the reference drug, gallic acid (IC\n                    <jats:sub>50<\/jats:sub>\n                    of 29.48\u00a0\u00b1\u00a00.014\u00a0\u00b5M), with an IC\n                    <jats:sub>50<\/jats:sub>\n                    of 33.14\u00a0\u00b1\u00a00.002\u00a0\u00b5M. The structure\u2013activity relationship (SAR) analysis revealed that electron\u2010donating substituents, particularly methoxy groups, enhance antimicrobial and antioxidant activity through improved molecular interactions. In silico absorption, distribution, metabolism, excretion, and toxicity (ADMET) evaluation further indicated that compound\n                    <jats:bold>2e<\/jats:bold>\n                    possesses favorable pharmacokinetic properties, including good membrane permeability and oral absorption, despite moderate solubility and predicted hERG liability.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202503308","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T09:01:53Z","timestamp":1769418113000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Synthesis, In Vitro Antimicrobial, and Antioxidant Activities of Novel Thiazole Derivatives"],"prefix":"10.1002","volume":"23","author":[{"given":"Abd\u00fcllatif","family":"Karakaya","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy Zonguldak Bulent Ecevit University  Zonguldak Turkey"},{"name":"Institute of Graduate Education Anadolu University  Eskisehir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emine Rana","family":"Ba\u011fc\u0131","sequence":"additional","affiliation":[{"name":"Institute of Graduate Education Anadolu University  Eskisehir Turkey"},{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy Afyonkarahisar Health Sciences University  Afyonkarahisar Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pervin","family":"Soyer","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Microbiology, Faculty of Pharmacy Anadolu University  Eski\u015fehir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nour El\u2010Huda","family":"Daoud","sequence":"additional","affiliation":[{"name":"Institute of Graduate Education Anadolu University  Eskisehir Turkey"},{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy Anadolu University  Eski\u015fehir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tu\u011fba","family":"Er\u00e7etin","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Eastern Mediterranean University  Famagusta North Cyprus Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulviye","family":"ACAR \u00c7EV\u0130K","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy Anadolu University  Eski\u015fehir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(20)30752\u20102"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867043455774"},{"key":"e_1_2_8_4_1","first-page":"277","article-title":"The Antibiotic Resistance Crisis: Part 1: Causes and Threats","volume":"40","author":"Ventola C. 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