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Initially, 9\u2010DOM showed no cytotoxic activity in RAW264.7 macrophages. In implants treated with 0.1\u00a0\u00b5g of 9\u2010DOM, a reduction in macrophage activity and in the average number of mast cells were observed. In addition, a pro\u2010fibrogenic effect was observed, with an increase in the synthesis and deposition of collagen, particularly thinner collagen fibers. None of the doses evaluated were able to alter the parameters associated with angiogenesis assessed. Although initial, the data demonstrates the low toxicity of 9\u2010DOM and its possible therapeutic application in situations where exacerbated inflammation and low collagen synthesis and deposition can compromise tissue repair.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202503329","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T11:41:16Z","timestamp":1767872476000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["9\u2010Deoxymuzigadial, a Sesquiterpene Isolated From\n                    <i>Drimys brasiliensis<\/i>\n                    (Winteraceae), Displays Reduced Cytotoxicity In Vitro and Modulates Leukocyte Activity and Fibrogenesis In Vivo"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8773-6704","authenticated-orcid":false,"given":"Bruno Antonio","family":"Ferreira","sequence":"first","affiliation":[{"name":"Center for Natural and Human Sciences Federal University of the ABC  Santo Andre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9427-267X","authenticated-orcid":false,"given":"Isabella Silva","family":"Cassimiro","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences Federal University of Uberl\u00e2ndia  Uberl\u00e2ndia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2127-4310","authenticated-orcid":false,"given":"Francyelle Borges Rosa","family":"de Moura","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology Federal University of Catal\u00e3o  Catal\u00e3o Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tais","family":"de Campos Lima","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences Federal University of Uberl\u00e2ndia  Uberl\u00e2ndia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle Reis","family":"Napolitano","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences Federal University of Uberl\u00e2ndia  Uberl\u00e2ndia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Umehara","sequence":"additional","affiliation":[{"name":"Center for Natural and Human Sciences Federal University of the ABC  Santo Andre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1193-8374","authenticated-orcid":false,"given":"Jo\u00e3o Henrique Ghilardi","family":"Lago","sequence":"additional","affiliation":[{"name":"Center for Natural and Human Sciences Federal University of the ABC  Santo Andre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3212-7079","authenticated-orcid":false,"given":"Fernanda de Assis","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Federal University of S\u00e3o Jo\u00e3o Del\u2010Rei  Divin\u00f3polis Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1039\/b311170a"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.02.010"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4NP00066H"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20184367"},{"key":"e_1_2_9_6_1","first-page":"1","volume-title":"Flora Ilustrada Catarinense","author":"Trinta E. 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