{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T19:49:15Z","timestamp":1778010555202,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21937002"],"award-info":[{"award-number":["21937002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773599"],"award-info":[{"award-number":["81773599"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In a previous phytochemical investigation, several structurally diverse diterpenoids were reported from the vulnerable relict conifer\n                    <jats:italic>Tsuga forrestii<\/jats:italic>\n                    (Forrest's hemlock). However, a previously undescribed co\u2010occurring C\u201015 carboxylated bisabolane\u2010type sesquiterpene (tsugaforrestolide,\n                    <jats:bold>1<\/jats:bold>\n                    ), featuring a 12,9\u2010lactone moiety in its lateral chain, remained unreported. The chemical structure and absolute configuration of\n                    <jats:bold>1<\/jats:bold>\n                    were unambiguously elucidated through a combination of spectroscopic techniques, GIAO NMR calculations with DP4+ probability analysis, electronic circular dichroism (ECD) data, and single\u2010crystal x\u2010ray diffraction analysis. As the first sesquiterpenoid isolated from hemlock species,\n                    <jats:bold>1<\/jats:bold>\n                    exhibited pronounced anti\u2010inflammatory activity, effectively inhibiting LPS\u2010induced nitric oxide (NO) production in RAW 264.7 macrophages, with an IC\n                    <jats:sub>50<\/jats:sub>\n                    value of 7.1\u00a0\n                    <jats:italic>\u00b5<\/jats:italic>\n                    M, comparable to the known inhibitor BAY11\u20107082 (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a08.7\u00a0\n                    <jats:italic>\u00b5<\/jats:italic>\n                    M). This finding further highlights the importance of conserving and sustainably utilizing this endangered plant species.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202503341","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T17:29:25Z","timestamp":1763659765000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Tsugaforrestolide, an Anti\u2010Inflammatory Bisabolane\u2010Type Sesquiterpene Lactone From the Vulnerable Conifer\n                    <i>Tsuga forrestii<\/i>"],"prefix":"10.1002","volume":"23","author":[{"given":"Peng\u2010Jun","family":"Zhou","sequence":"first","affiliation":[{"name":"Key Laboratory of Endangered Plants Sustainable Utilization of Taizhou, Institute of Natural Medicine and Health Products, School of Pharmaceutical Sciences Taizhou University  Zhejiang People's Republic of China"},{"name":"School of Chemical Engineering Sichuan University of Science &amp; Engineering  Zigong People's Republic of China"},{"name":"School of Pharmacy Fudan University  Shanghai People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ze\u2010Yu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Endangered Plants Sustainable Utilization of Taizhou, Institute of Natural Medicine and Health Products, School of Pharmaceutical Sciences Taizhou University  Zhejiang People's Republic of China"},{"name":"School of Pharmacy Fudan University  Shanghai People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhe\u2010Lu","family":"Jiang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Endangered Plants Sustainable Utilization of Taizhou, Institute of Natural Medicine and Health Products, School of Pharmaceutical Sciences Taizhou University  Zhejiang People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeun\u2010Mun","family":"Choo","sequence":"additional","affiliation":[{"name":"Chemistry Department Faculty of Science University of Malaya  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Xiong","sequence":"additional","affiliation":[{"name":"School of Pharmacy Fudan University  Shanghai People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0367-1454","authenticated-orcid":false,"given":"Jin\u2010Feng","family":"Hu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Endangered Plants Sustainable Utilization of Taizhou, Institute of Natural Medicine and Health Products, School of Pharmaceutical Sciences Taizhou University  Zhejiang People's Republic of China"},{"name":"School of Chemical Engineering Sichuan University of Science &amp; Engineering  Zigong People's Republic of China"},{"name":"School of Pharmacy Fudan University  Shanghai People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2025.114453"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.3c00181"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2021.12.009"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2019.112184"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1107336108"},{"key":"e_1_2_9_7_1","unstructured":"The IUCN Red List of Threatened Species Version 2025\u20101.https:\/\/www.iucnredlist. org\/search?query=Tsuga&searchType=species."},{"key":"e_1_2_9_8_1","volume-title":"China Plant Red Data Book. 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