{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T08:57:30Z","timestamp":1785488250586,"version":"3.56.0"},"reference-count":56,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Gentiana scabra<\/jats:italic>\n                    Bge.,\n                    <jats:italic>Gentiana triflora<\/jats:italic>\n                    Pall.,\n                    <jats:italic>Gentiana manshurica<\/jats:italic>\n                    Kitag., and\n                    <jats:italic>Gentiana rigescens<\/jats:italic>\n                    Franch. were recorded as Gentianae Radix et Rhizome (Longdan) in Chinese Pharmacopoeia (ChP) and controlled by gentiopicroside (GPS). Owing to similar contents of GPS among these herbs, the demand for an effective method for Longdan classification and quality control remains urgent. In this study, we prepared the extract rich in phenolic components from four species herbs. UPLC\u2013Q\u2010TOF\u2013MS analysis and bioactive evaluation revealed that Longdan phenolic extracts possess distinct phytochemical profiles and anti\u2010inflammatory efficacy. After that, mangiferin, kaempferol, ferulic acid, and esculetin were selected as bioactivity\u2010related components and potential quality markers for Longdan herbs. Subsequently, 16 batches of Longdan materials were quantitatively analyzed based on the contents of characteristic phenolic compounds. By means of chemometric analysis (circular heat map, principal component analysis [PCA], and hierarchical clustering), 16 batches of Longdan herbs could be well classified according to differences in phenolic index compounds (PICs). Furthermore, with the help of network pharmacology analysis, the underlying in vivo targets and gene pathways of PICs were illustrated. Thus, the systematic importance of Longdan phenolic components and usefulness of PICs for herbs differentiating were clarified and the established method is helpful for the quality control of Gentianae Radix et Rhizome.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202503342","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T14:37:41Z","timestamp":1768401461000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Insights Into Phenolic Components of Gentianae Radix Et Rhizoma: Chemotaxonomic Markers Exploring Based on UPLC\u2013Q\u2010TOF\u2013MS Profiling and HPLC Quantification Coupled With Chemometric Analysis, and Anti\u2010Inflammatory Mechanism Digesting Using Network Pharmacology Analysis Approach"],"prefix":"10.1002","volume":"23","author":[{"given":"Yifang","family":"Min","sequence":"first","affiliation":[{"name":"College of Life Science and Technology Beijing University of Chemical Technology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Li","sequence":"additional","affiliation":[{"name":"College of Life Science and Technology Beijing University of Chemical Technology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiyu","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Life Science and Technology Beijing University of Chemical Technology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao","family":"Gao","sequence":"additional","affiliation":[{"name":"College of Life Science and Technology Beijing University of Chemical Technology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kehan","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Life Science and Technology Beijing University of Chemical Technology  Beijing 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