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All the synthetic derivatives attributed noteworthy inhibition except compounds\n                    <jats:bold>(11<\/jats:bold>\n                    ,\n                    <jats:bold>14<\/jats:bold>\n                    and\n                    <jats:bold>16)<\/jats:bold>\n                    , while eight compounds (\n                    <jats:bold>5<\/jats:bold>\n                    ,\n                    <jats:bold>6<\/jats:bold>\n                    ,\n                    <jats:bold>7<\/jats:bold>\n                    ,\n                    <jats:bold>8<\/jats:bold>\n                    ,\n                    <jats:bold>19<\/jats:bold>\n                    ,\n                    <jats:bold>24<\/jats:bold>\n                    ,\n                    <jats:bold>22<\/jats:bold>\n                    and\n                    <jats:bold>18<\/jats:bold>\n                    ) were found potent comparing them with the standard kojic acid. Furthermore, the remaining nine compounds showed good to less inhibitory activity. A\n                    <jats:italic>para\u2010nitro<\/jats:italic>\n                    containing compound\n                    <jats:bold>5<\/jats:bold>\n                    attributed the powerful tyrosinase inhibition through docking and normal mode analysis (NMA). It formed stable electrostatic interactions and hydrogen bonds that decline catalytic flexibility, as well as stabilising the enzyme in an inactive site. NMA showed disrupted strong intra\u2010domain coupling and global motions, signifying a broad stabilisation of the enzyme structure. Compared to kojic acid, compound\n                    <jats:bold>5<\/jats:bold>\n                    displayed enhanced binding stability, lower B\u2010factors and tighter packing. A robust correlation (\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u00a0=\u00a00.8754) among the IC\n                    <jats:sub>50<\/jats:sub>\n                    values and binding energy authenticated the computational model and its potential for rational inhibitor design.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202503358","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:53:46Z","timestamp":1790855626000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>tris\u2010<\/i>\n                    Schiff Base Derivatives Containing Flurbiprofen as Potential Tyrosinase Inhibitors: Synthesis, In Vitro Evaluation, Molecular Docking, DFT and Dynamics Simulations"],"prefix":"10.1002","volume":"23","author":[{"given":"Aftab","family":"Alam","sequence":"first","affiliation":[{"name":"Department of Chemistry Rawalpindi Women University  Rawalpindi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Ayaz","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Malakand  Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Zainab","sequence":"additional","affiliation":[{"name":"College of Chemistry and Materials Science Hebei Normal University  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majid","family":"Khan","sequence":"additional","affiliation":[{"name":"College of Chemistry Fuzhou University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed A.","family":"Elhenawy","sequence":"additional","affiliation":[{"name":"Chemistry Department Faculty of Science Al\u2010Azhar University  Cairo Egypt"},{"name":"Chemistry Department Faculty of Science Al\u2010Baha University  Al\u2010Bahah Saudi 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