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Based on single\u2010factor experiments, response surface methodology optimized ultrasound\u2010assisted extraction conditions for corn silk polysaccharides (CSP): liquid\u2010to\u2010solid 43\u00a0mL\/g, extraction time 3\u00a0h, and ultrasonic power 640\u00a0W, yielding 5.83% CSP. Sulfated, phosphorylated, and selenylated derivatives (CSP\u2010S, CSP\u2010P, and CSP\u2010Se) were prepared with substitution degrees of 0.6 and 0.4, and selenium content of 5.3%, respectively. After confirming structures by UV, FT\u2010IR, SEM, monosaccharide, and Congo\u2010red analyses, the bioactivities of the modified CSP were compared. All derivatives improved antioxidant capacity in vitro: phosphorylation boosted DPPH scavenging, while sulfation enhanced hydroxyl and superoxide anion radical elimination. Selenylation markedly inhibited the activities of \u03b1\u2010amylase and lipase, and promoted glucose consumption in HepG2 cells, demonstrating hypoglycemic potential. 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