{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T12:45:44Z","timestamp":1775997944053,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study provides an analysis of the endemic plant\u00a0\n                    <jats:italic>Mattiastrum paphlagonicum<\/jats:italic>\n                    \u00a0Bornm.(Synonym\u00a0\n                    <jats:italic>Paracaryum paphlagonicum<\/jats:italic>\n                    \u00a0(Bornm.) R.R. Mill), focusing on enzyme activity, secondary metabolite content, antioxidant capacity (DPPH, ABTS, and FRAP), as well as phenolic and flavonoid levels, all within the context of\u00a0a hydroethanolic extract prepared from\u00a0\n                    <jats:italic>M. paphlagonicum<\/jats:italic>\n                    and\u00a0its biodiversity, for the first time. Rosmarinic acid and rutin were identified at concentrations of 87.56\u00a0\u00b1\u00a00.09\u00a0 and 0.96\u00a0\u00b1\u00a00.15\u00a0mg\/g of the plant extract, respectively. The total polyphenol and flavonoid contents were measured as 0.85\u00a0\u00b1\u00a00.004\u00a0mg gallic acid equivalent\/mL and 0.077\u00a0\u00b1\u00a00.014\u00a0mg rutin equivalent\/mL. The extract exhibited exceptionally strong DPPH radical\u2010scavenging activity, with a value of 231.746 \u00b1 0.009\u00a0mg ascorbic acid equivalents (AAE)\/mL extract, and high ferric reducing antioxidant power (FRAP), reaching 168.229 \u00b1 0.004\u00a0mg AAE\/mL extract. The percentage inhibition for tyrosinase and carbonic anhydrase by the extract was 97.6\u00a0\u00b1\u00a00.011% and 77.07\u00a0\u00b1\u00a00.996%, respectively. The extract is a rich source of bioactive compounds and has considerable inhibitory effects on tyrosinase and carbonic anhydrase enzymes. These findings highlight the plant's potential for neuroprotective and renoprotective pharmacological applications.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202503371","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T07:28:50Z","timestamp":1773905330000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neuroprotective and Renoprotective Potential of a Hydroethanolic Extract From the Aerial Parts of\n                    <i>Mattiastrum paphlagonicum<\/i>\n                    Bornm. (Boraginaceae)"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3555-4399","authenticated-orcid":false,"given":"Ay\u015fenur","family":"Kayaba\u015f Av\u015far","sequence":"first","affiliation":[{"name":"Department of Biology, Faculty of Science \u00c7ank\u0131r\u0131 Karatekin University  \u00c7ank\u0131r\u0131 T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9427-3119","authenticated-orcid":false,"given":"Eda","family":"B\u00fcker","sequence":"additional","affiliation":[{"name":"Department of Basic Pharmaceutical Sciences, Faculty of Pharmacy Gazi University  Ankara T\u00fcrkiye"},{"name":"Enzymology and Applied Biocatalysis Research Center, Faculty of Chemistry and Chemical Engineering Babe\u015f Bolyai University  Cluj\u2010Napoca Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4083-3408","authenticated-orcid":false,"given":"Ertan","family":"Yildirim","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science Gazi University  Ankara T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7056-8000","authenticated-orcid":false,"given":"Dorina","family":"Casoni","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Chemistry and Chemical Engineering Babe\u015f\u2010Bolyai University  Cluj\u2010Napoca Romania"},{"name":"Research Centre for Advanced Chemical Analysis, Instrumentation and Chemometrics\u2013Analytica Babe\u015f\u2010Bolyai University  Cluj\u2010Napoca Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona Codruta Aurora","family":"Cobzac","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Chemistry and Chemical Engineering Babe\u015f\u2010Bolyai University  Cluj\u2010Napoca Romania"},{"name":"Research Centre for Advanced Chemical Analysis, Instrumentation and Chemometrics\u2013Analytica Babe\u015f\u2010Bolyai University  Cluj\u2010Napoca Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2025.106877"},{"key":"e_1_2_9_3_1","unstructured":"POWO Plant of the World Online accessed on February 12 2026 https:\/\/powo.science.kew.org\/."},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules29215088"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.55730\/1300\u2010008X.2807"},{"key":"e_1_2_9_6_1","unstructured":"A.G\u00fcner S.Aslan T.Ekim M.Vural andM. 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