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The crosslinking of chia seed glucoxylan (GX) and hydroxypropyl cellulose (HPC) with citric acid (CA) was carried out using three different concentrations of CA, that is, 1%, 5% and 10% w\/v. The FTIR spectroscopy, powder x\u2010ray diffraction (PXRD), thermogravimetric analysis (TGA) and SEM analyses confirmed the successful formation of GX\u2013HPC\u2013CL\u2013CA, amorphous nature, greater stability over native GX and porous structure, respectively. Among the three formulations, the GX\u2013HPC\u2013CL\u2013CA\u20102 (prepared from 5% CA) offered the highest swelling capacity and followed by the pattern: deionized water (DW)\u00a0&gt;\u00a0pH 7.4\u00a0&gt;\u00a0pH 6.8\u00a0&gt;\u00a0pH 1.2. The GX\u2013HPC\u2013CL\u2013CA\u20102 and GX\u2013HPC\u2013CL\u2013CA\u20102\u2010based tablet possessed pH\u2010responsive swelling, salt\u2010responsive swelling and on\/off switching (swelling\u2013deswelling) behaviour at pH 7.4\/1.2, in DW\/normal saline and in DW\/ethanol. The theophylline release was found to be 16.8%, 92.1% and 98.3% at pH 1.2, 6.8 and 7.4, respectively, after an 8\u00a0h study, indicating a pH\u2010dependent release, followed the first\u2010order kinetics and a non\u2010Fickian diffusion mechanism. The GX\u2013HPC\u2013CL\u2013CA\u20102 appeared to be a non\u2010thrombogenic, non\u2010haemolytic and non\u2010toxic material, demonstrating a haemocompatible and pH\u2010responsive bio\u2010composite hydrogel for developing site\u2010specific and sustained\u2010release DDS.<\/jats:p>","DOI":"10.1002\/cbdv.202503389","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T21:39:47Z","timestamp":1770327587000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Citric Acid\u2013Mediated Crosslinking of Chia Seed Glucoxylan and Hydroxypropyl Cellulose: pH Responsiveness, Haemocompatibility and Sustained Drug Release"],"prefix":"10.1002","volume":"23","author":[{"given":"Arshad","family":"Ali","sequence":"first","affiliation":[{"name":"Institute of Chemistry University of Sargodha  Sargodha 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