{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T12:46:19Z","timestamp":1775997979086,"version":"3.50.1"},"reference-count":53,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The investigation examined the protective potential of aqueous extract of\n                    <jats:italic>Morinda lucida<\/jats:italic>\n                    leaf (ML) on aluminium chloride (AlCl\n                    <jats:sub>3<\/jats:sub>\n                    )\u2010mediated testicular damage in rats (male) and determined if its secondary metabolites could modulate proteins linked with erectile dysfunction. Rats in the treatment groups were administered 30\u00a0mg\/kg bw AlCl\n                    <jats:sub>3<\/jats:sub>\n                    , with doses of 125\u00a0mg\/kg bw and 250\u00a0mg\/kg bw of the plant extract. Phytocompounds identified in the plant were also screened for potential phosphodiesterase\u20105 and arginase inhibitor molecules. After 21 days of treatment, sperm count in the animal group treated with only AlCl\n                    <jats:sub>3<\/jats:sub>\n                    decreased significantly, though with no effect on sperm motility. Administration of ML improved sperm morphology in the extract\u2010treated group compared to the untreated group. Moreover, the leaf extract reversed the elevated myeloperoxidase activity, IL\u20106, TNF\u2010\u03b1, and nitrite concentration observed in the untreated group to near control levels in the plant treatment groups. Molecular docking analysis showed that stigmasterol (\u221210.2\u00a0kcal\/mol) and oruwacin (\u22128.2\u00a0kcal\/mol) had the best respective binding energies against the phosphodiesterase\u20105 and arginase proteins. The 300\u00a0ns dynamics simulation further revealed the compounds' good stability at the enzymes\u2019 active sites. Further experiments will be required to determine the potential alternative therapeutic interventions of the plant in preserving male fertility.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202503399","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T07:16:58Z","timestamp":1774509418000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Morinda lucida<\/i>\n                    Leaf Metabolites Ameliorate Aluminium Chloride\u2010Mediated Chronic Inflammation and Modulate Proteins\u2010Linked to Erectile Dysfunction in Rat Testes"],"prefix":"10.1002","volume":"23","author":[{"given":"Kayode E.","family":"Adewole","sequence":"first","affiliation":[{"name":"Faculty of Basic Medical Sciences Department of Biochemistry University of Medical Sciences  Ondo Ondo State Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayodeji O.","family":"Falade","sequence":"additional","affiliation":[{"name":"Faculty of Basic Medical Sciences Department of Biochemistry University of Medical Sciences  Ondo Ondo State Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sola N.","family":"Falekulo","sequence":"additional","affiliation":[{"name":"Faculty of Basic Medical Sciences Department of Biochemistry University of Medical Sciences  Ondo Ondo State Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olubunmi F.","family":"Gbadebo","sequence":"additional","affiliation":[{"name":"Faculty of Basic Medical Sciences Department of Biochemistry University of Medical Sciences  Ondo Ondo State Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aimen","family":"Aljoundi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Salerno  Fisciano SA Italy"},{"name":"Faculty of Pharmacy Department of Medicinal Chemistry University of Tripoli  Tripoli Libya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghazi","family":"Elamin","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry College of Pharmacy Karary University  Khartoum Sudan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2987-0996","authenticated-orcid":false,"given":"Kolawole A.","family":"Olofinsan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology University of the Free State  Bloemfontein South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.2478\/intox-2019-0007"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0531.2011.01878.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.13930"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4377-1604-7.00021-X"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2004.11.007"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2007.07.011"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2014.10.001"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sxmr.2017.05.004"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imu.2023.101190"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.114055"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hermed.2014.08.001"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2017.06.026"},{"issue":"48","key":"e_1_2_11_14_1","first-page":"3452","article-title":"Chemical Constituents and Biological Activity of Medicinal Plants Used for the Management of Sickle Cell Disease\u2010A Review","volume":"7","author":"Folashade K. 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