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In this study, we applied an integrative bioinformatic pipeline combining cross\u2010cohort differential expression analysis, high\u2010confidence protein\u2013protein interaction network reconstruction, and topological hub\u2010gene prioritization. Hub candidates were then intersected with curated target repertoires of multi\u2010target chemicals (notably quercetin and sulforaphane [SFN]) to nominate pharmacologically accessible \u201celite\u201d targets. Downstream in silico validation included comparative mRNA and protein expression profiling, correlations with immune infiltration metrics, survival prognostic assessments, and molecular docking to evaluate ligand\u2010target complementarity. This multilayered approach consistently highlighted extracellular matrix remodeling, integrin\u2010mediated adhesion, and pericellular proteolysis as central processes in PAAD biology and identified\n                    <jats:italic>COL1A1<\/jats:italic>\n                    ,\n                    <jats:italic>ITGA2<\/jats:italic>\n                    , and\n                    <jats:italic>PLAU<\/jats:italic>\n                    as top\u2010priority targets that combine high network centrality with overlap to phytochemical target spaces. These genes demonstrated tumor\u2010enriched expression, adverse survival associations, and distinct immune\u2013microenvironment correlations, suggesting a potential involvement in pro\u2010tumorigenic remodeling processes. Molecular docking analyses suggested computationally feasible ligand\u2013target binding hypotheses, with quercetin exhibiting comparatively stronger predicted affinities than SFN across all targets.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202503423","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T09:19:37Z","timestamp":1773393577000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Integrative Bioinformatic Identification and Molecular Docking of Quercetin and Sulforaphane\u2010Associated Prognostic Targets in Pancreatic Adenocarcinoma"],"prefix":"10.1002","volume":"23","author":[{"given":"Murat","family":"Is\u0131yel","sequence":"first","affiliation":[{"name":"Faculty of Science Department of Molecular Biology and Genetics Atat\u00fcrk University  Erzurum 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