{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T07:02:32Z","timestamp":1775890952942,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007224","name":"National Foundation for Science and Technology Development","doi-asserted-by":"publisher","award":["104.01\u20102023.06"],"award-info":[{"award-number":["104.01\u20102023.06"]}],"id":[{"id":"10.13039\/100007224","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Psychotria serpens<\/jats:italic>\n                    , a significant traditional Vietnamese plant, exhibits anti\u2010inflammatory properties and is clinically used to treat rheumatism and sciatica. However, its bioactive components remain poorly understood. In this study, phytochemical investigation of\n                    <jats:italic>P. serpens<\/jats:italic>\n                    leaves led to the isolation and structural elucidation of eight iridoid glucosides (\n                    <jats:bold>1<\/jats:bold>\n                    \u2013\n                    <jats:bold>8<\/jats:bold>\n                    ), including two previously undescribed compounds, psychoserpen A (\n                    <jats:bold>1<\/jats:bold>\n                    ) and B (\n                    <jats:bold>2<\/jats:bold>\n                    ). Their structures were elucidated by a combination of IR, HRESIMS, and 1D\u2010 and 2D\u2010nuclear magnetic resonance (NMR) analyses. This is the first report of compounds\n                    <jats:bold>4<\/jats:bold>\n                    ,\n                    <jats:bold>7<\/jats:bold>\n                    , and\n                    <jats:bold>8<\/jats:bold>\n                    from the genus\n                    <jats:italic>Psychotria<\/jats:italic>\n                    and compounds\n                    <jats:bold>3<\/jats:bold>\n                    ,\n                    <jats:bold>5<\/jats:bold>\n                    , and\n                    <jats:bold>6<\/jats:bold>\n                    from\n                    <jats:italic>P. serpens<\/jats:italic>\n                    species. All the isolated compounds significantly inhibited nitric oxide (NO) production on lipopolysaccharide (LPS)\u2010stimulated RAW 264.7 macrophage with IC\n                    <jats:sub>50<\/jats:sub>\n                    values ranging from 27.2 to 61.4\u00a0\u00b5M.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202503452","type":"journal-article","created":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T03:51:01Z","timestamp":1765597861000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Psychoserpens A and B: Two New Iridoids From the Leaves of\n                    <i>Psychotria serpens<\/i>\n                    L. That Inhibit Nitric Oxide Production"],"prefix":"10.1002","volume":"23","author":[{"given":"Pham The","family":"Chinh","sequence":"first","affiliation":[{"name":"Thai Nguyen University of Sciences\u2010TNU  Thai Nguyen Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pham Thi","family":"Tham","sequence":"additional","affiliation":[{"name":"Faculty of Chemical Technology Hanoi University of Industry  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vu Quang","family":"Tung","sequence":"additional","affiliation":[{"name":"Thai Nguyen University of Sciences\u2010TNU  Thai Nguyen Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen Thi Thu","family":"Thuy","sequence":"additional","affiliation":[{"name":"Thai Nguyen University of Sciences\u2010TNU  Thai Nguyen Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dinh Thuy","family":"Van","sequence":"additional","affiliation":[{"name":"Thai Nguyen University of Sciences\u2010TNU  Thai Nguyen Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vu Tuan","family":"Kien","sequence":"additional","affiliation":[{"name":"Thai Nguyen University of Sciences\u2010TNU  Thai Nguyen Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cao Thanh","family":"Hai","sequence":"additional","affiliation":[{"name":"Thai Nguyen University of Sciences\u2010TNU  Thai Nguyen Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phan Thi Thanh","family":"Huong","sequence":"additional","affiliation":[{"name":"Institute of Chemistry, VAST  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bui Huu","family":"Tai","sequence":"additional","affiliation":[{"name":"Institute of Chemistry, VAST  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0756-6990","authenticated-orcid":false,"given":"Phan","family":"Van Kiem","sequence":"additional","affiliation":[{"name":"Institute of Chemistry, VAST  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,12]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"1307","article-title":"Dictionary of Vietnamese Medicinal Plants","volume":"1","author":"Chi V. V.","year":"2018","journal-title":"Medical Publishing House"},{"key":"e_1_2_8_3_1","first-page":"4878","article-title":"Chemical Constituents From Stems and Leaves of Psychotria serpens","volume":"43","author":"Zhou B. D.","year":"2018","journal-title":"China Journal of Chinese Materia Medica"},{"key":"e_1_2_8_4_1","first-page":"60","article-title":"Flavonoids From Psychotria Serpens L., a Herbal Medicine With Anti\u2010Cancer Activity","volume":"4","author":"Lin C. Z.","year":"2015","journal-title":"Journal of Cancer Research Updates"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20102006\u2010962441"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2019.1574789"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.50.1395"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/np010479o"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2013.03.001"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202401679"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/np0780046"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.39.2049"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.15625\/2525-2518\/56\/4\/11164"},{"key":"e_1_2_8_14_1","first-page":"525","article-title":"Iridoids, Flavonoids and Monoterpene Glycosides From Galium verum subsp. Verum","volume":"30","author":"Demirezer L. 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