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For the coordination capability, HL bonded to Cu\n                    <jats:sup>2+<\/jats:sup>\n                    and\n                    <jats:italic>cis<\/jats:italic>\n                    \u2010MoO\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>2+<\/jats:sup>\n                    cations for the design of two new complexes of CuL and\n                    <jats:italic>cis<\/jats:italic>\n                    \u2010MoO\n                    <jats:sub>2<\/jats:sub>\n                    L, respectively. The inhibitive action of HL (as a free organic reagent) impacted by its complexing forms in CuL and\n                    <jats:italic>cis<\/jats:italic>\n                    \u2010MoO\n                    <jats:sub>2<\/jats:sub>\n                    L on the proliferating capacity of various microorganism series and normal\/tumor cell lines of humankind was examined, and their antioxidant capacity was evaluated. Consequently, Cu\n                    <jats:sup>2+<\/jats:sup>\n                    and\n                    <jats:italic>cis<\/jats:italic>\n                    \u2010MoO\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>2+<\/jats:sup>\n                    cations exhibited modified biochemical actions against the developed proliferation of the bacterial\u2010fungal and tumor cells over the uncoordinated HL ligand through the measured areas of microorganisms\u2019 dead zones (mm) and the half\u2010maximal inhibitory concentrations (\n                    <jats:italic>IC<\/jats:italic>\n                    <jats:sub>50<\/jats:sub>\n                    , \u00b5M) of the proliferated tumor cell lines in vitro, spectroscopically. The affinity of binding strength and modes of HL, CuL, and\n                    <jats:italic>cis<\/jats:italic>\n                    \u2010MoO\n                    <jats:sub>2<\/jats:sub>\n                    L with calf thymus DNA (ctDNA) were estimated by the variations in the viscometric and colorimetric characteristics of the current compounds, referring to the obvious effect of Cu\n                    <jats:sup>2+<\/jats:sup>\n                    and\n                    <jats:italic>cis<\/jats:italic>\n                    \u2010MoO\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>2+<\/jats:sup>\n                    cations with their high electronegativity and redox potential. Spectroscopic analyses were employed to examine the interaction of HL, CuL, and\n                    <jats:italic>cis<\/jats:italic>\n                    \u2010MoO\n                    <jats:sub>2<\/jats:sub>\n                    L with ctDNA through the derived data of\n                    <jats:italic>K<\/jats:italic>\n                    <jats:sub>b<\/jats:sub>\n                    and , as 1.31, 1.55, and 1.61 \u00d7 10\n                    <jats:sup>6<\/jats:sup>\n                    mol\n                    <jats:sup>\u2212<\/jats:sup>\n                    <jats:sup>1<\/jats:sup>\n                    dm\n                    <jats:sup>3<\/jats:sup>\n                    , and as \u221240.14, \u221244.38, and \u221245.43\u00a0kJ mol\n                    <jats:sup>\u2212<\/jats:sup>\n                    <jats:sup>1<\/jats:sup>\n                    , respectively. Hence, Cu\n                    <jats:sup>2+<\/jats:sup>\n                    and\n                    <jats:italic>cis<\/jats:italic>\n                    \u2010MoO\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>2+<\/jats:sup>\n                    cations demonstrated a significant influence on the biological action of their complexes based on their different charges, oxidation states, and coordination geometries relative to the uncoordinated organic HL ligand.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202503487","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T11:21:13Z","timestamp":1777548073000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dinuclear Copper(II) and Molybdenum(VI) Complexes of Bis\u2010Tridentate Hydrazonylthiophene: Synthesis and Biochemical 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