{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T09:09:15Z","timestamp":1788858555233,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T00:00:00Z","timestamp":1786752000000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Diabetes mellitus characterizes a key universal health concern associated with severe metabolic complications. In this current study, a biogenic approach was employed to synthesize silver nanoparticles (AgNPs) using rifabutin as both a reducing and stabilizing agent. The resulting Rifabutin\u2010AgNPs were thoroughly characterized by UV\u2013vis spectroscopy, x\u2010ray diffraction (XRD), scanning electron microscopy (SEM), and Fourier\u2010transform infrared spectroscopy (FTIR), confirming their crystalline nature and functional group interactions responsible for nanoparticle stabilization. The antidiabetic potential of the synthesized Rifabutin\u2010AgNPs was evaluated in streptozotocin (STZ)\u2010induced diabetic rats. Oral administration of Rifabutin\u2010AgNPs (5 and 10 mg\/kg) for 14 days produced a significant, dose\u2010dependent reduction in blood glucose levels, improved serum lipid profiles, and normalized hepatic transaminase (SGOT and SGPT) activities compared with untreated diabetic controls. The superior therapeutic efficacy of Rifabutin\u2010AgNPs over pure rifabutin highlights the potential of this green synthesized nanoformulation as an efficient platform for diabetes management at the chemical biological interface.<\/jats:p>","DOI":"10.1002\/cbdv.202503503","type":"journal-article","created":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T17:12:47Z","timestamp":1786813967000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Rifabutin Loaded Biogenic Silver Nanoparticles: Development, Characterization, and Evaluation of Antidiabetic Activity in Streptozotocin Induced Diabetic Rats"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2421-2921","authenticated-orcid":false,"given":"Ayushi","family":"Maurya","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Science, Faculty of Health Science Sam Higginbottom University of Agriculture Technology and Sciences  Prayagraj India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2872-7733","authenticated-orcid":false,"given":"Mohd. Ibrahim","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Science, Faculty of Health Science Sam Higginbottom University of Agriculture Technology and Sciences  Prayagraj India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3462-034X","authenticated-orcid":false,"given":"Saif Mohammed Saleh","family":"Ansari","sequence":"additional","affiliation":[{"name":"Laboratory Animal Facility Sam Higginbottom University of Agriculture Technology and Sciences  Prayagraj India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9549-1567","authenticated-orcid":false,"given":"Mohd. Faiyaz","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, College of Pharmacy Prince Sattam Bin Abdulaziz University  Al\u2010Kharj Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8181-8374","authenticated-orcid":false,"given":"Faten F.","family":"Bin Dayel","sequence":"additional","affiliation":[{"name":"Department of Pharmacology &amp; Toxicology, College of Pharmacy Prince Sattam Bin Abdulaziz University  Al\u2010Kharj Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0710-6048","authenticated-orcid":false,"given":"Wedad","family":"Mawkili","sequence":"additional","affiliation":[{"name":"Department of Pharmacology &amp; Toxicology, College of Pharmacy Jazan University  Jazan Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3912-2977","authenticated-orcid":false,"given":"Norah A.","family":"Ghazwani","sequence":"additional","affiliation":[{"name":"Department of Pharmacology &amp; Toxicology, College of Pharmacy Jazan University  Jazan Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8023-0935","authenticated-orcid":false,"given":"Nazia","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Science Ibn Sina National College for Medical Studies  Jeddah Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9086-3624","authenticated-orcid":false,"given":"Shanti Bhushan","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy United Institute of Pharmacy  Prayagraj India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1297-4837","authenticated-orcid":false,"given":"Saim","family":"Kidwai","sequence":"additional","affiliation":[{"name":"Hamdard Institute of Medical Sciences and Research Jamia Hamdard  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4268-9163","authenticated-orcid":false,"given":"Danish","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Science, Faculty of Health Science Sam Higginbottom University of Agriculture Technology and Sciences  Prayagraj India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,15]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijo.IJO_1627_21"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2019.107843"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2021.05.012"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2021.109119"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.7555\/JBR.31.20160164"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2017.12.003"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2591"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2016.108"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943\u2010025\u201002368\u2010w"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010018\u201003705\u2010y"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2012.03.020"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28104203"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2016.07.008"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21062217"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano11082130"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/cryst13111576"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.5772\/intechopen.1002203"},{"key":"e_1_2_12_19_1","first-page":"1","volume-title":"Green Synthesis, Characterization and Applications of Nanoparticles","author":"Pal G.","year":"2018"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011\u2010023\u201003645\u20109"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eti.2022.102336"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkaa370"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jia2.25333"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.17925\/EE.2013.09.02.76"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325\u2010013\u20100009\u20104"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjbas.2017.04.010"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S198194"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27144336"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0220950"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0300115"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2021.06.017"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics10020057"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202402361"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1088\/2043\u20106254\/ab47ff"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.54085\/ap.2024.13.1.59"},{"key":"e_1_2_12_36_1","volume-title":"Spectrometric Identification of Organic Compounds","author":"Silverstein R. M.","year":"2014"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25020904"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1590\/0001\u20103765201820170598"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17091534"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano13010100"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/8460910"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010022\u201024818\u2010x"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28134995"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2022.962112"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010023\u201029412\u20103"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1194809"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S231340"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parepi.2017.09.001"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph16121677"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S212614"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S87268"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202503503","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbdv.202503503","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202503503","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T08:29:33Z","timestamp":1788856173000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.202503503"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":50,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/cbdv.202503503"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.202503503","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"2025-10-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e03503"}}