{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T08:01:49Z","timestamp":1785484909688,"version":"3.56.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T00:00:00Z","timestamp":1768694400000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Quinoxaline is an aza\u2010heterocycle found in some bioactive compounds. Thus, to enhance the pharmacological scope of this nucleus, we report a series of 19 acetamides decorated with a quinoxaline core. The synthesis involved the linkage of previously constructed bromoacetamides and hydroxyphenyl quinoxalines via an S\n                    <jats:sub>N<\/jats:sub>\n                    2 reaction. The first series considered a 1,4\u2010substituted phenyl ring as a linker, and some derivatives showed moderate antibacterial activity against a panel of ESKAPE pathogens, especially against methicillin\u2010resistant\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (inhibition ranging from 10% to 60% at 100 \u00b5M). Interestingly, the activity dropped in the 1,3\u2010 and 1,2\u2010regioisomers. Furthermore, we tested the series against relevant human cancer cell lines, in which the ethyl derivative\n                    <jats:bold>10c<\/jats:bold>\n                    inhibited the growth of breast, prostate, and colon tumors (43%, 48%, and 66%, respectively), whereas COS\u20107 cells showed only 7.8% inhibition. Although these are preliminary in vitro findings, we corroborate the applicability of the quinoxaline heterocycle in the design of potential candidates against relevant pathologies.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202503511","type":"journal-article","created":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T09:17:47Z","timestamp":1768727867000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Synthesis of 2\u2010(Quinoxalin\u20102\u2010yl)acetamides and Their Preliminary Cytotoxic and Antibacterial Activity"],"prefix":"10.1002","volume":"23","author":[{"given":"Cesar E.","family":"Tovar\u2010Roman","sequence":"first","affiliation":[{"name":"Departamento De Qu\u00edmica Org\u00e1nica Instituto De Qu\u00edmica, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM)  Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0463-9448","authenticated-orcid":false,"given":"Eduardo","family":"Hern\u00e1ndez\u2010V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Departamento De Qu\u00edmica Org\u00e1nica Instituto De Qu\u00edmica, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM)  Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 A.","family":"Rivera\u2010Ch\u00e1vez","sequence":"additional","affiliation":[{"name":"Departamento De Productos Naturales Instituto De Qu\u00edmica, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM)  Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.116329"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.112829"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43094\u2010021\u201000335\u2010y"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.3c05883"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm501100b"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25081909"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.5b01742"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2017.11.064"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2010.01.042"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2022.133578"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1RA06799"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.13921"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2013.06.048"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2024.116675"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rechem.2024.101989"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.11.059"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2009.06.007"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202501173"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2024.2395985"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2020.153031"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2025.109116"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2021.105105"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.202400879"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1RA07559D"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00044\u2010022\u201002997\u20106"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201800634"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2022.105963"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1RA07559D"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.6b00709"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.23690"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2024.105384"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33587"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2021.127899"}],"container-title":["Chemistry &amp; 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