{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T07:00:32Z","timestamp":1775890832404,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T00:00:00Z","timestamp":1766188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T00:00:00Z","timestamp":1766188800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Fermentation of the deep\u2010sea fungus\n                    <jats:italic>Subuliphorum<\/jats:italic>\n                    sp. SCSIO 41053 on rice medium yielded two novel metabolites, aspergiamide G (\n                    <jats:bold>1<\/jats:bold>\n                    ) and palitantin D (\n                    <jats:bold>6<\/jats:bold>\n                    ), along with 12 previously reported compounds (\n                    <jats:bold>2<\/jats:bold>\n                    \u2013\n                    <jats:bold>5<\/jats:bold>\n                    and\n                    <jats:bold>7<\/jats:bold>\n                    \u2013\n                    <jats:bold>14<\/jats:bold>\n                    ). Comprehensive spectroscopic analyses, including nuclear magnetic resonance, mass spectrometry, and electronic circular dichroism, were used to establish the chemical structures and stereochemistry, which were corroborated by literature comparison. Biological evaluation revealed that compounds\n                    <jats:bold>4<\/jats:bold>\n                    ,\n                    <jats:bold>6<\/jats:bold>\n                    , and\n                    <jats:bold>9<\/jats:bold>\n                    exhibited moderate cytotoxicity against the mouse melanoma cell line (B16F10), with half\u2010maximal inhibitory concentration values of 10.07 \u00b1 1.68, 10.93 \u00b1 5.60, and 30.00 \u00b1 7.33\u00a0\u00b5M, respectively. Molecular docking studies suggested that compounds\n                    <jats:bold>4<\/jats:bold>\n                    and\n                    <jats:bold>6<\/jats:bold>\n                    interact strongly with the active site of tyrosinase, a key enzyme in melanogenesis, highlighting their potential as enzyme inhibitors.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202503516","type":"journal-article","created":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T17:44:21Z","timestamp":1766252661000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cytotoxic Diketopiperazine Alkaloids and Polyketides Isolated From the Deep\u2010Sea Fungus\n                    <i>Subuliphorum<\/i>\n                    sp. SCSIO 41053"],"prefix":"10.1002","volume":"23","author":[{"given":"Ying\u2010Ying","family":"Song","sequence":"first","affiliation":[{"name":"Guangxi Key Laboratory of Marine Drugs Institute of Marine Drugs Guangxi University of Chinese Medicine  Nanning P. R. China"},{"name":"University Engineering Research Center of High\u2010Efficient Utilization of Marine Traditional Chinese Medicine Resources  Nanning P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen\u2010Zhou","family":"Tang","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Marine Drugs Institute of Marine Drugs Guangxi University of Chinese Medicine  Nanning P. R. China"},{"name":"University Engineering Research Center of High\u2010Efficient Utilization of Marine Traditional Chinese Medicine Resources  Nanning P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiang\u2010Lian","family":"She","sequence":"additional","affiliation":[{"name":"Guangdong Key Laboratory of Marine Materia Medica, State Key Laboratory of Tropical Oceanography South China Sea Institute of Oceanology, Chinese Academy of Sciences  Guangzhou P. R. China"},{"name":"University of Chinese Academy of Sciences  Beijing P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Liu","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Marine Drugs Institute of Marine Drugs Guangxi University of Chinese Medicine  Nanning P. R. China"},{"name":"University Engineering Research Center of High\u2010Efficient Utilization of Marine Traditional Chinese Medicine Resources  Nanning P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7524-8049","authenticated-orcid":false,"given":"Cheng\u2010Hai","family":"Gao","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Marine Drugs Institute of Marine Drugs Guangxi University of Chinese Medicine  Nanning P. R. China"},{"name":"University Engineering Research Center of High\u2010Efficient Utilization of Marine Traditional Chinese Medicine Resources  Nanning P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun\u2010Feng","family":"Wang","sequence":"additional","affiliation":[{"name":"Guangdong Key Laboratory of Marine Materia Medica, State Key Laboratory of Tropical Oceanography South China Sea Institute of Oceanology, Chinese Academy of Sciences  Guangzhou P. R. China"},{"name":"University of Chinese Academy of Sciences  Beijing P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong\u2010Hong","family":"Liu","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Marine Drugs Institute of Marine Drugs Guangxi University of Chinese Medicine  Nanning P. R. China"},{"name":"University Engineering Research Center of High\u2010Efficient Utilization of Marine Traditional Chinese Medicine Resources  Nanning P. R. China"},{"name":"Guangdong Key Laboratory of Marine Materia Medica, State Key Laboratory of Tropical Oceanography South China Sea Institute of Oceanology, Chinese Academy of Sciences  Guangzhou P. R. China"},{"name":"University of Chinese Academy of Sciences  Beijing P. R. 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