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To overcome these limitations, a novel pH\u2010responsive colorimetric hydrogel (polyvinyl alcohol\/chitosan\/curcumin liposome [PVA\/CS\/CL]) was developed by incorporating CLs into a PVA\/CS matrix. The optimized CL showed high encapsulation efficiency (95.04%\u00a0\u00b1\u00a02.26%) and uniform particle size (121.51\u00a0\u00b1\u00a08.66\u00a0nm). The resulting hydrogel exhibited pH\u2010dependent color changes (yellow to reddish\u2010brown), improved mechanical strength (Young's modulus: 24.108\u00a0\u00b1\u00a01.572\u00a0kPa), and enhanced water retention (340.35%\u00a0\u00b1\u00a020.12%). In vitro studies demonstrated pH\u2010responsive drug release (61.37%\u00a0\u00b1\u00a05.56% at pH 5.5 vs. 43.96%\u00a0\u00b1\u00a04.10% at pH 7.4), following the Korsmeyer\u2013Peppas kinetics. The hydrogel also showed excellent biocompatibility (cell viability\u00a0&gt;\u00a088%), strong antibacterial activity (&gt;90% inhibition), and high antioxidant capacity (1,1\u2010diphenyl\u20102\u2010picrylhydrazyl [DPPH] scavenging: 85.64%\u00a0\u00b1\u00a04.68%). This dual\u2010functional system provides a promising platform for wound management and inflammatory therapy.<\/jats:p>","DOI":"10.1002\/cbdv.202503530","type":"journal-article","created":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T00:39:47Z","timestamp":1765586387000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Curcumin Liposome\u2013Embedded Polyvinyl Alcohol\/Chitosan Hydrogel Exhibiting pH\u2010Responsive Sustained Drug Release and Antioxidant\u2013Antibacterial Activity"],"prefix":"10.1002","volume":"23","author":[{"given":"Yuan","family":"Sun","sequence":"first","affiliation":[{"name":"China Zhejiang Provincial Engineering Research Center of New Technologies and Applications for Targeted Therapy of Major Diseases Zhejiang Sci\u2010Tech University  Hangzhou China"},{"name":"Laboratory of Anti\u2010Allergy Functional Compounds, College of Life Sciences and Medicine Zhejiang Sci\u2010Tech University 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