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In the present study, the hydroethanolic extract of\n                    <jats:italic>C. angustifolia<\/jats:italic>\n                    leaves, its solvent\u2010partitioned fractions, and the flavonoids acacetin and acacetin\u20107\u2010\n                    <jats:italic>O<\/jats:italic>\n                    \u2010rutinoside, reported herein for the first time in this species, were investigated for their antiradical and cytotoxic activities. Among the fractions, the ethyl acetate fraction exhibited the highest total phenolic content (633.7\u00a0mg GAE\/g) and the strongest radical scavenging activity (EC\n                    <jats:sub>50<\/jats:sub>\n                    : 2.0 \u00b5g\/mL). Comparative evaluation of the isolated flavonoids revealed that acacetin\u20107\u2010\n                    <jats:italic>O<\/jats:italic>\n                    \u2010rutinoside displayed superior antiradical activity relative to its aglycone, suggesting that C\u20107 glycosylation may enhance radical scavenging capacity. Cytotoxic assays demonstrated that the crude extract was most active against MCF\u20107 breast cancer cells (IC\n                    <jats:sub>50<\/jats:sub>\n                    : 37.2 \u00b5g\/mL), while the chloroform fraction showed selective inhibitory activity against SK\u2010Mel\u201028 melanoma cells (IC\n                    <jats:sub>50<\/jats:sub>\n                    : 36.3 \u00b5g\/mL). In contrast, the isolated flavonoids exhibited weak or selective cytotoxic effects, indicating that the biological activity of the extracts is likely attributable to synergistic interactions among multiple constituents. Overall, these findings expand the phytochemical knowledge of\n                    <jats:italic>C. angustifolia<\/jats:italic>\n                    and highlight its potential as a source of bioactive phenolic compounds.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202503539","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T19:01:36Z","timestamp":1771268496000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Isolation, Antiradical Activity, and Cytotoxicity of Flavonoids From\n                    <i>Cunila angustifolia<\/i>"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2366-8754","authenticated-orcid":false,"given":"Matheus H. 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D.","family":"Freitas","sequence":"additional","affiliation":[{"name":"Natural Products Research Group Universidade Federal do Rio Grande  Rio Grande Rio Grande do Sul Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karina","family":"Cesca","sequence":"additional","affiliation":[{"name":"Universidade Federal de Santa Catarina  Florian\u00f3polis Santa Catarina Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neusa F.","family":"de Moura","sequence":"additional","affiliation":[{"name":"Natural Products Research Group Universidade Federal do Rio Grande  Rio Grande Rio Grande do Sul Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-18617-2_11"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2024.2360149"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2006.09.032"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436\u2010009\u20101455\u20104"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/10412905.2021.1928558"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031\u20109422(00)97769\u20100"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.118991"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0305\u20101978(03)00003\u20106"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1590\/1983\u2010084X\/15_126"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.14522\/darwiniana.2014.391\u20102.206"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/10412905.2008.9700016"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1603\/ME12277"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.201900656"},{"key":"e_1_2_9_15_1","first-page":"19","volume-title":"Antioxidantes: Aspectos Qu\u00edmicos, Farmacol\u00f3gicos e Terap\u00eauticos","author":"Cit\u00f3 A. 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