{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:51:27Z","timestamp":1787770287765,"version":"build-2784847793"},"reference-count":52,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Current aromatase inhibitors (AIs) are limited by poor bioavailability and high toxicity, underscoring the need for the development of new therapeutics. In the present study, a series of 12 benzimidazole\u2010pyrazole hybrids was designed, synthesized, and structurally characterized using infrared spectroscopy, mass spectrometry, nuclear magnetic resonance spectroscopy, and elemental analysis. Their anti\u2010breast cancer potential was evaluated against the MCF\u20107 cell line using the MTT assay. Notably, compounds\n                    <jats:bold>5g<\/jats:bold>\n                    and\n                    <jats:bold>5i<\/jats:bold>\n                    exhibited the highest cytotoxicity, reflected by the lowest IC\n                    <jats:sub>50<\/jats:sub>\n                    values, while showing minimal toxicity toward the normal cell line, NIH3T3. Aromatase inhibitory activity, assessed using the fluorometric assay, further identified compound\n                    <jats:bold>5g<\/jats:bold>\n                    as the most potent inhibitor. Complementary molecular docking studies demonstrated that compounds\n                    <jats:bold>5g<\/jats:bold>\n                    and\n                    <jats:bold>5i<\/jats:bold>\n                    form favorable interactions with the aromatase enzyme, showing higher binding affinity compared to letrozole, providing mechanistic insight into their inhibitory activity. ADMET analysis further confirmed the drug\u2010likeness and pharmacokinetic suitability of the synthesized derivatives. Collectively, these results establish compound\n                    <jats:bold>5g<\/jats:bold>\n                    as a promising lead for aromatase inhibition, necessitating further in vivo evaluation.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202503557","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T16:30:01Z","timestamp":1775061001000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Design, Synthesis, and Biological Evaluation of Benzimidazole\u2010Pyrazole Hybrids as Aromatase Inhibitors for Breast Cancer Therapy"],"prefix":"10.1002","volume":"23","author":[{"given":"Supriya","family":"Sharma","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy Parul University Waghodia  Vadodara Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay Prakash","family":"Soni","sequence":"additional","affiliation":[{"name":"Department of Biochemistry University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milind J.","family":"Umekar","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics Smt. Kishoritai Bhoyar College of Pharmacy New Kamptee  Nagpur Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uma Dhiraj","family":"Kabra","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Parul Institute of Pharmacy Parul University Waghodia Vadodara Gujarat India"},{"name":"Department of Pharmaceutical Chemistry Smt. 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