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Essential oils, particularly those of\n                    <jats:italic>Mentha piperita<\/jats:italic>\n                    , are well recognized for their antimicrobial and wound\u2010healing properties. This scoping review mapped the available evidence on the use of topical formulations containing\n                    <jats:italic>M. piperita<\/jats:italic>\n                    \u2010derived products for wound healing, with a focus on formulation vehicles, concentrations, experimental models, and efficacy parameters. Following JBI and PRISMA\u2010ScR guidelines, a comprehensive search was conducted in PubMed, Scopus, Web of Science, and LILACS (2010\u20132025). Twenty studies met the inclusion criteria, the majority of which were preclinical, comprising in vitro (35%), in vivo (30%), and combined in vitro\/in vivo (30%) models. Only one ex vivo study was identified, and no clinical trials were found. The formulations investigated ranged from creams and gels to nanoemulsions, lipid carriers, films, and nanofibers, with concentrations varying from 0.5% to 20%.\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    was the most frequently tested strain and showed greater susceptibility to peppermint essential oil (PEO). Incorporation into nanostructured systems was associated with improved stability, enhanced skin permeation, and superior antimicrobial performance, particularly when combined with nanoparticles, metals, other bioactive compounds, or, in specific cases, clinical antibiotics such as levofloxacin. Across both infected wound models and noninfected wound\u2010healing models,\n                    <jats:italic>M. piperita<\/jats:italic>\n                    \u2010containing formulations were associated with favorable outcomes, although the underlying mechanisms differed depending on the presence or absence of microbial challenge. Despite these promising findings, significant gaps remain regarding ex vivo validation, safety assessment, and clinical translation. Overall, PEO demonstrates considerable potential as an antimicrobial and wound\u2010healing agent; however, more standardized and clinically oriented studies are required.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202503567","type":"journal-article","created":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T22:12:12Z","timestamp":1769897532000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Topical Formulations Containing\n                    <i>Mentha piperita<\/i>\n                    for Wound Healing: A Scoping Review"],"prefix":"10.1002","volume":"23","author":[{"given":"Lorena Gon\u00e7alves","family":"Ara\u00fajo","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Universidade Federal do Maranh\u00e3o  S\u00e3o Lu\u00eds Brazil"},{"name":"Laborat\u00f3rio de Imunofisiologia Universidade Federal do Maranh\u00e3o  S\u00e3o Lu\u00eds Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz Gomes","family":"Vila\u2010Nova","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunofisiologia Universidade Federal do Maranh\u00e3o  S\u00e3o Lu\u00eds Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1665-0879","authenticated-orcid":false,"given":"Afonso Gomes","family":"Abreu","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade, Universidade Federal do Maranh\u00e3o  S\u00e3o Lu\u00eds Brazil"},{"name":"Laborat\u00f3rio de Imunofisiologia Universidade Federal do Maranh\u00e3o  S\u00e3o Lu\u00eds 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