{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T07:02:32Z","timestamp":1775890952972,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Ferula<\/jats:italic>\n                    is a genus of flowering plants known for its edible and medicinal properties. The gum of the\n                    <jats:italic>Ferula kokanica<\/jats:italic>\n                    was selected for this study based on its traditional uses. From the gum of\n                    <jats:italic>F. kokanica<\/jats:italic>\n                    , an undescribed sesquiterpene coumarin was isolated, named kokanin A, along with 22 known compounds. Structure elucidation of the isolated compounds was carried out by one\u2010 and two\u2010dimensional nuclear magnetic resonance and high\u2010resolution\u2010electrospray ionization\u2010mass spectrometry data analysis. Using NOE correlation, the relative configurations of the isolated compounds were established. The absolute configurations of isolates were established by electronic circular dichroism calculation. Cytotoxicity and anti\u2010vitiligo activity of the isolated compounds were tested. Gummosin demonstrated strong cytotoxicity against the HT\u201029 cell line with IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 6.96 \u00b1 0.38 \u00b5M. Colladonin, farnesiferol A, and feshurin provided greater relative melanin content than that of the positive control at 50 \u00b5M. The elemental composition of the gum of\n                    <jats:italic>F. kokanica<\/jats:italic>\n                    using the inductively coupled plasma mass spectrometry method allowed the determination of trace levels of As, Cd, Cu, Hg, Pb, Na, Mg, K, and Ca. The toxic elements were determined in the sample, and their content was found to be lower than the maximum acceptable concentration established by the World Health Organization. This study showed that some isolated compounds demonstrated significant anti\u2010vitiligo activity and showed promise for future drug discovery. To our knowledge, this is the first report on the chemical composition and the bioactivities of the gum of\n                    <jats:italic>F. kokanica<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202503573","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T10:39:57Z","timestamp":1770719997000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["New Sesquiterpene Coumarin From the Gum of\n                    <i>Ferula kokanica<\/i>"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4597-4047","authenticated-orcid":false,"given":"Sodik","family":"Numonov","sequence":"first","affiliation":[{"name":"State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization Xinjiang Technical Institute of Physics and Chemistry  Urumqi China"},{"name":"Chinese\u2010Tajik Innovation Center for Natural Products of the National Academy of Sciences of Tajikistan  Dushanbe Tajikistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khushang","family":"Ashurov","sequence":"additional","affiliation":[{"name":"State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization Xinjiang Technical Institute of Physics and Chemistry  Urumqi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farukh","family":"Sharopov","sequence":"additional","affiliation":[{"name":"Chinese\u2010Tajik Innovation Center for Natural Products of the National Academy of Sciences of Tajikistan  Dushanbe Tajikistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunbula","family":"Atolikshoeva","sequence":"additional","affiliation":[{"name":"Chinese\u2010Tajik Innovation Center for Natural Products of the National Academy of Sciences of Tajikistan  Dushanbe Tajikistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maitinuer","family":"Maiwulanjiang","sequence":"additional","affiliation":[{"name":"State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization Xinjiang Technical Institute of Physics and Chemistry  Urumqi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7449-0936","authenticated-orcid":false,"given":"Khurshed","family":"Bozorov","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry, Samarkand State University  Samarkand Uzbekistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1625-0330","authenticated-orcid":false,"given":"Ibrohimjon","family":"Askarov","sequence":"additional","affiliation":[{"name":"Department of Chemistry Andijan State University  Andijan Uzbekistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4652-6879","authenticated-orcid":false,"given":"Haji Akber","family":"Aisa","sequence":"additional","affiliation":[{"name":"State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization Xinjiang Technical Institute of Physics and Chemistry  Urumqi China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2019.111511"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf803157j"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2018.12.012"},{"key":"e_1_2_9_5_1","first-page":"471","article-title":"Screening of Ferula Narthex Boiss Crude Methanolic Extract for Analgesic, Gastrointestinal Motility and Insecticidal Activity","volume":"14","author":"Bashir S.","year":"2013","journal-title":"Middle\u2010East Journal of Scientific Research"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00579439"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00575034"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2024.106035"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2012.02.016"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2016.1149705"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202200315"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202301841"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6492346"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm701494b"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/80200275"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2021.113739"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.100110"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2011.05.001"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.5625\/lar.2011.27.3.259"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2005.54"},{"key":"e_1_2_9_21_1","doi-asserted-by":"crossref","DOI":"10.1177\/1934578X0900401219","article-title":"The Cytotoxic Properties of Natural Coumarins Isolated From Roots of Ferulago campestris (Apiaceae) and of Synthetic Ester Derivatives of Aegelinol","volume":"4","author":"Rosselli S.","year":"2009","journal-title":"Natural Products Communications"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph17091252"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031\u20109422(01)00324\u20107"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2021.104829"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/13880200490886102"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/np990262i"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/np100487j"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2006.12.011"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/13880200902752884"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00563828"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2021.112705"},{"key":"e_1_2_9_32_1","first-page":"10","article-title":"Acetylcholinesterase Inhibitors From Galbanum, the Oleo Gum\u2010Resin of Ferula Gummosa Boiss","author":"Adhami H.\u2010R.","year":"2014","journal-title":"Phytochemistry Letters"},{"key":"e_1_2_9_33_1","unstructured":"Y.Hou N.Li X. R.Zhang andY.Xing \u201cSesquiterpene Coumarin Compounds From Ferula Sinkiangensis and Preparation and Application in the Treatment of Neurodegenerative Diseases Thereof \u201d (2015) CN104447655A."},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786410600823431"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6RA22502K"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00781101"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00941672"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/np50038a024"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031\u20109422(98)00489\u20100"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2007.03.047"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13010007"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11101\u2010024\u201010055\u20109"},{"key":"e_1_2_9_43_1","first-page":"446","article-title":"Gummosin, a Sesquiterpene Coumarin From Ferula Assa\u2010Foetida Is Preferentially Cytotoxic to Human Breast and Prostate Cancer Cell Lines","volume":"9","author":"Iranshahi M.","year":"2019","journal-title":"Avicenna Journal of Phytomedicines"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2007.11.023"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.112142"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.685116"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2019.01.067"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43247\u2010023\u201000723\u20107"},{"key":"e_1_2_9_49_1","volume-title":"Gaussian 09 Citation","author":"Frisch M.","year":"2013"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.4149\/gpb_2017008"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2024.139010"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202503573","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbdv.202503573","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202503573","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T06:36:47Z","timestamp":1775889407000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.202503573"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/cbdv.202503573"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.202503573","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"2025-11-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e03573"}}