{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T16:59:42Z","timestamp":1785085182596,"version":"3.55.0"},"reference-count":54,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    A practical and efficient approach was developed for the synthesis of novel 1,2\u2010oxaphospholene\u20102\u2010oxide derivatives, a class of oxygen\u2010 and phosphorus\u2010containing heterocycles. This\n                    <jats:italic>one pot<\/jats:italic>\n                    method, performed under microwave (MW) irradiation\u00a0using provides a rapid and eco\u2010compatible route to access these novel structures. The synthesized compounds were structurally confirmed through\n                    <jats:sup>1<\/jats:sup>\n                    H,\n                    <jats:sup>1<\/jats:sup>\n                    <jats:sup>3<\/jats:sup>\n                    C,\n                    <jats:sup>31<\/jats:sup>\n                    P NMR, IR, and MS analyses. Their biological potential was explored through antimicrobial and antioxidant evaluations. Several derivatives exhibited promising antibacterial and antifungal activities, particularly in inhibiting microbial growth and biofilm formation, while 2,2\u2010diphenyl\u20101\u2010pycrilhydrazyl (DPPH) assays revealed moderate to strong antioxidant activity. Complementary in silico studies, including molecular docking, provided insights into the binding affinities and possible interaction modes of the compounds with biological targets. Density functional theory (DFT) calculations further elucidated electronic structures and reactive sites, while ADMET (Absorption, Distribution, Metabolism, Toxicity) predictions using SwissADME highlighted favorable pharmacokinetic and drug\u2010likeness properties.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202503597","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T05:12:21Z","timestamp":1778044341000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Microwave\u2010Assisted Synthesis of Oxaphospholene\u20102\u2010Oxide Derivatives: Biological Evaluation, and In Silico Studies"],"prefix":"10.1002","volume":"23","author":[{"given":"Rayene","family":"Sayad","sequence":"first","affiliation":[{"name":"Laboratory of Applied Organic Chemistry, Bioorganic Chemistry Group, Sciences Faculty, Chemistry Department Badji Mokhtar Annaba University  Annaba Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zineb","family":"Aouf","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Organic Chemistry, Bioorganic Chemistry Group, Sciences Faculty, Chemistry Department Badji Mokhtar Annaba University  Annaba Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8908-8912","authenticated-orcid":false,"given":"Abdeslem","family":"Bouzina","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Organic Chemistry, Bioorganic Chemistry Group, Sciences Faculty, Chemistry Department Badji Mokhtar Annaba University  Annaba Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chahrazed","family":"Benzaid","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology and Molecular Biology Badji Mokhtar Annaba University  Annaba Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manel Lina","family":"Djendi","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology and Molecular Biology Badji Mokhtar Annaba University  Annaba Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachida","family":"Zerrouki","sequence":"additional","affiliation":[{"name":"Univ. 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