{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T21:56:18Z","timestamp":1790546178464,"version":"4.1.0"},"reference-count":79,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Endophytic fungi are recognized as prolific sources of structurally diverse secondary metabolites with significant pharmaceutical potential. In the present study, endophytic fungi were isolated from healthy tissues of\n                    <jats:italic>Atalantia racemosa<\/jats:italic>\n                    (Rutaceae), an ethnomedicinal plant traditionally used for respiratory disorders and blood purification. A total of three fungal isolates were obtained and identified as\n                    <jats:italic>Aspergillus flavus<\/jats:italic>\n                    ,\n                    <jats:italic>Pleosporales<\/jats:italic>\n                    sp., and\n                    <jats:italic>Endothia<\/jats:italic>\n                    sp. based on morphological and molecular (ITS sequencing) analyses. Crude extracts of the isolates were subjected to phytochemical characterization using GC\u2013MS, FTIR, and LC\u2013MS techniques. GC\u2013MS profiling revealed the presence of fatty acids, sterols, phenolics, and terpenoids, while FTIR analysis confirmed key functional groups such as hydroxyl, carbonyl, and aromatic moieties. Importantly, LC\u2013MS analysis provided high\u2010resolution metabolite profiling, identifying diverse bioactive compounds including alkaloids, flavonoids, quinic acid derivatives, xanthones (mangostin derivatives), phenolic amides (N\u2010feruloyl\u2010octopamine), diterpenoids, chalcones, macrolides, and terpene lactones in both positive and negative ionization modes. Biological evaluation demonstrated notable antioxidant, antibacterial, anti\u2010inflammatory, anticancer, and wound healing activities, with\n                    <jats:italic>Endothia<\/jats:italic>\n                    sp. showing superior anticancer activity (IC\n                    <jats:sub>50<\/jats:sub>\n                    : 19.37\u00a0\u00b5g\/mL) and significant wound healing potential. The integration of LC\u2013MS data highlights the metabolic diversity and pharmacological relevance of these fungal isolates. Overall, the study confirms that endophytic fungi associated with\n                    <jats:italic>A. racemosa<\/jats:italic>\n                    are promising sources of bioactive metabolites with potential applications in drug discovery.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202503604","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T10:21:08Z","timestamp":1789035668000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Phytochemical Profiling and Evaluation of Antibacterial, Anticancer, Anti\u2010inflammatory, and Wound\u2010Healing Activities of Endophytic Fungi Isolated From\n                    <i>Atalantia racemosa<\/i>"],"prefix":"10.1002","volume":"23","author":[{"given":"Sushma","family":"M","sequence":"first","affiliation":[{"name":"P G Department of Studies in Biotechnology and Microbiology Karnatak University  Dharwad Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun","family":"Shettar","sequence":"additional","affiliation":[{"name":"Multidisciplinary Research Unit Karnataka Medical College and Research Institute  Hubli Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joy","family":"Hoskeri","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics and Biotechnology Karnataka State Akkamahadevi Women's University  Vijayapura Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vedamurthy","family":"A B","sequence":"additional","affiliation":[{"name":"P G Department of Studies in Biotechnology and Microbiology Karnatak University  Dharwad Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/mmbr.67.4.491\u2010502.2003"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1017\/S095375620500273X"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbr.2007.05.003"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.2307\/3545919"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.2307\/1943155"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.5958\/J.0975\u20106892.5.2.013"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2002.2006"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469\u20108137.2009.02773.x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3767\/003158513X666844"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/np030397v"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3923\/ajbmb.2011.291.309"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/np070669k"},{"key":"e_1_2_11_14_1","volume-title":"Encyclopaedia of World Medicinal Plants","author":"Pullaiah T.","year":"2006"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.7324\/JAPS.2013.3830"},{"key":"e_1_2_11_16_1","first-page":"707","article-title":"Ethno\u2010medicinal Survey Among Palliyar Tribals of Srivilliputhur Grizzled Giant Squirrel Wildlife Sanctuary, Tamil Nadu","volume":"27","author":"Arinathan V.","year":"2003","journal-title":"Journal of Economic and Taxonomic Botany"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/b100918o"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253\u2010011\u20103270\u2010y"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.67.4.491\u2010502.2003"},{"key":"e_1_2_11_20_1","first-page":"1239","article-title":"Endophytic Fungi From Citrus Species and Their Bioactivity","volume":"29","author":"Kumar S.","year":"2013","journal-title":"World Journal of Microbiology and Biotechnology"},{"key":"e_1_2_11_21_1","first-page":"1","article-title":"Endophytic Fungi From Medicinal Plants: Diversity and Bioactivity","volume":"33","author":"Suryanarayanan T. 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