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The bioactive phytochemicals of acetone, ethanol and water extracts of\n                    <jats:italic>C. monogyna<\/jats:italic>\n                    were determined through validated LC\u2013MS\/MS method. The highest total phenolic (80.92\u00a0mg GAE\/g) and flavonoid content (51.94\u00a0mg RE\/g) was observed with the ethanol extract. The best antioxidant capability was observed for ethanol extract in DPPH (334.72\u00a0mg TE\/g), ABTS (442.58\u00a0mg TE\/g), CUPRAC (666.09\u00a0mg TE\/g), FRAP (328.04\u00a0mg TE\/g), and phosphomolybdenum (2.77\u00a0mmol TE\/g). In addition, enzyme inhibition properties of different extracts of\n                    <jats:italic>C. monogyna<\/jats:italic>\n                    were checked for acetylcholinesterase (AChE), butyrylcholinesterase (BChE), tyrosinase, amylase, and glucosidase. While the most effective AChE inhibition was observed in ethanol extract (2.92\u00a0mg GALAE\/g), it was noted that the most effective BChE inhibition was acetone extract (2.34\u00a0mg GALAE\/g). The best tyrosinase inhibition was detected in the water extract with 79.09\u00a0mg KAE\/g. The tested extracts exhibited antidiabetic potentials by amylase (0.22\u20130.29\u00a0mmol ACAE\/g) and glucosidase inhibition (3.29\u20133.37\u00a0mmol ACAE\/g). The chemical reactivities of the dominant molecular components in all extracts were illuminated in the light of DFT calculations and the interaction with related biological systems of these molecular structures were analyzed with the help of molecular docking analyses.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202503625","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T21:27:13Z","timestamp":1770326833000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Phytochemical Composition and Multi\u2010Target Biological Activities of\n                    <i>Crataegus monogyna<\/i>\n                    : LC\u2013MS\/MS, DFT, and Molecular Docking Approaches"],"prefix":"10.1002","volume":"23","author":[{"given":"Emre Can","family":"Buluz","sequence":"first","affiliation":[{"name":"Department of Biotechnology Institute of Science, Ege University  \u0130zmir T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Handan","family":"Sara\u00e7","sequence":"additional","affiliation":[{"name":"Department of Plant and Animal Production Sivas Cumhuriyet University  Sivas T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet","family":"Demirba\u015f","sequence":"additional","affiliation":[{"name":"Department of Plant and Animal Production Sivas Cumhuriyet University  Sivas T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00f6khan","family":"Zengin","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science Sel\u00e7uk University  Konya T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa Abdullah","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Faculty of Pharmacy Dicle University  Diyarbak\u0131r T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O\u011fuz","family":"Cakir","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, Faculty of Health Sciences Dicle University  Diyarbak\u0131r T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. M.","family":"Maslov","sequence":"additional","affiliation":[{"name":"National Research Nuclear University \u201cMEPhI\u201d  Moscow Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0765-9751","authenticated-orcid":false,"given":"Sava\u015f","family":"Kaya","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science Sivas Cumhuriyet University  Sivas 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