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Two key steps for the synthesis of the isochromans were utilized. (i) The benzylic bromination of methyl 2\u2010methoxy\u20106\u2010pentadecylbenzoate was accomplished with N\u2010bromosuccinimide in the green solvent tert\u2010butyl acetate to afford methyl 2\u2010methoxy\u20106\u2010(pentadec\u20101\u2010en\u20101\u2010yl)benzoate. (ii) Exposure of the secondary alcohol 1\u2010(2\u2010methoxy\u20106\u2010(pentadec\u20101\u2010en\u20101\u2010yl)phenyl)ethanol to potassium tert\u2010butoxide resulted in the formation of the isochroman, trans\u20108\u2010methoxy\u20101\u2010methyl\u20102\u2010tridecylisochroman. In a similar manner, the related isochroman, trans\u20108\u2010methoxy\u20101,3\u2010dimethylisochroman, could be synthesized. Selected antifungal and antibacterial testing showed moderate activities.<\/jats:p>","DOI":"10.1002\/cbdv.202503670","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T16:59:34Z","timestamp":1773680374000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis of Isochromans From Anacardic Acids Obtained From Cashew Nutshell Liquid (CNSL) and Their Antimicrobial Activity"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9525-9151","authenticated-orcid":false,"given":"Bianca L.","family":"Davids","sequence":"first","affiliation":[{"name":"Molecular Sciences Institute School of Chemistry University of the Witwatersrand  Johannesburg South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianqi","family":"Lu","sequence":"additional","affiliation":[{"name":"Molecular Sciences Institute School of Chemistry University of the 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