{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T02:48:19Z","timestamp":1783046899723,"version":"3.54.6"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    A novel library of new indazole\u2014sulfonamides were synthesized by as single step protocol and evaluated their invitro anticancer activity against three breast cancer cell lines viz. MCF\u20107, MDA\u2010MB\u2010231, and SKBR\u20103 cell employing Lapatinib as standard reference. Compounds\n                    <jats:bold>3f<\/jats:bold>\n                    established promising activity against all the three cell lines with an IC\n                    <jats:sub>50<\/jats:sub>\n                    value of\n                    <jats:bold>10.77\u00a0\u00b1\u00a00.31\u00a0\u00b5M<\/jats:bold>\n                    (MCF\u20107),\n                    <jats:bold>10.82\u00a0\u00b1\u00a00.47\u00a0\u00b5M<\/jats:bold>\n                    (MDA\u2010MB\u2010231), and\n                    <jats:bold>11.10\u00a0\u00b1\u00a00.49\u00a0\u00b5M<\/jats:bold>\n                    (SKBR\u20103). Compound\n                    <jats:bold>3d<\/jats:bold>\n                    had shown effective activity with an IC\n                    <jats:sub>50<\/jats:sub>\n                    value of\n                    <jats:bold>11.40\u00a0\u00b1\u00a00.53<\/jats:bold>\n                    (MCF\u20107),\n                    <jats:bold>11.25\u00a0\u00b1\u00a00.51<\/jats:bold>\n                    (MDA\u2010MB\u2010231), and\n                    <jats:bold>12.32\u00a0\u00b1\u00a00.33\u00a0\u00b5M<\/jats:bold>\n                    (SKBR\u20103). Compound\n                    <jats:bold>3<\/jats:bold>\n                    \u00a0\n                    <jats:bold>h<\/jats:bold>\n                    demonstrated potent activity with an IC\n                    <jats:sub>50<\/jats:sub>\n                    value of\n                    <jats:bold>13.42\u00a0\u00b1\u00a00.25<\/jats:bold>\n                    (MCF\u20107),\n                    <jats:bold>12.97\u00a0\u00b1\u00a00.23<\/jats:bold>\n                    (MDA\u2010MB\u2010231), and\n                    <jats:bold>13.05\u00a0\u00b1\u00a00.37<\/jats:bold>\n                    \u00a0\n                    <jats:bold>\u00b5M<\/jats:bold>\n                    (SKBR\u20103). Additionally, performed molecular docking study against crystal structure of PARP15 to get insights into molecular binding interactions, it accomplished promising docking scores and binding interactions such as H\u2010bond and hydrophobic in support of experimental investigations.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202503697","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T12:44:29Z","timestamp":1772973869000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Design and Synthesis of Novel Indazole\u2014Sulfonamide Derivatives, Cytotoxicity, and Molecular Docking Insights"],"prefix":"10.1002","volume":"23","author":[{"given":"Venkata Reddy","family":"Satti","sequence":"first","affiliation":[{"name":"Department of Chemistry Koneru Lakshmaiah Education Foundation  Hyderabad Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0992-0842","authenticated-orcid":false,"given":"Mohammad Saim","family":"Raza","sequence":"additional","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology Roorkee  Roorkee Uttarakhand India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3147-7613","authenticated-orcid":false,"given":"Km","family":"Roshani","sequence":"additional","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology Roorkee  Roorkee Uttarakhand India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishna Chaitanya","family":"Veeranki","sequence":"additional","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology Roorkee  Roorkee Uttarakhand India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3060-795X","authenticated-orcid":false,"given":"Tanmoy","family":"Mondal","sequence":"additional","affiliation":[{"name":"Department of Chemistry Koneru Lakshmaiah Education Foundation  Hyderabad Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23112783"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/10406638.2025.2532069"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2022.114597"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2023.135327"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568026621666211214151534"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568026622666220512145646"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2013.03.075"},{"key":"e_1_2_8_9_1","doi-asserted-by":"crossref","unstructured":"L. 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