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Conventional biotechnological procedures allowed the identification of 17 fungal species, and chemical analysis permitted the isolation of plant and fungal metabolites, characterizing 20 compounds. The inhibition of the SARS\u2010CoV\u20102 spike protein:ACE2 complex was evaluated using a Ray Biotech kit, and the cytotoxicity against selected tumor cell lines was evaluated by use of the sulforhodamine B assay. The chemical analysis of\n                    <jats:italic>T. mucronatum<\/jats:italic>\n                    afforded diterpenes (\n                    <jats:bold>1<\/jats:bold>\n                    \u2013\n                    <jats:bold>6<\/jats:bold>\n                    ), cycloartanes (\n                    <jats:bold>7<\/jats:bold>\n                    \u2010\n                    <jats:bold>\u201010<\/jats:bold>\n                    , not previously reported for this species), and sterols (\n                    <jats:bold>11<\/jats:bold>\n                    ,\n                    <jats:bold>12<\/jats:bold>\n                    ). Complementing that analysis, endophytic fungi were identified, mainly from the genus\n                    <jats:italic>Penicillium<\/jats:italic>\n                    , and compounds\n                    <jats:bold>13<\/jats:bold>\n                    \u2013\n                    <jats:bold>20<\/jats:bold>\n                    were isolated from some of the fungal cultures. The PASS calculations predicted antiviral activity for compounds\n                    <jats:bold>5<\/jats:bold>\n                    ,\n                    <jats:bold>8<\/jats:bold>\n                    ,\n                    <jats:bold>10<\/jats:bold>\n                    , and\n                    <jats:bold>12<\/jats:bold>\n                    , and cytotoxic activity for almost all the isolated compounds. The in vitro results indicate that\n                    <jats:italic>T. mucronatum<\/jats:italic>\n                    and some of its endophytic fungi constitute new sources of bioactive substances that inhibit the formation of the SARS\u2010CoV\u20102 spike protein:ACE2 complex (such as taxodione,\n                    <jats:bold>3<\/jats:bold>\n                    ) and inhibitors of certain cancer cell lines (\n                    <jats:bold>5<\/jats:bold>\n                    ,\n                    <jats:bold>13<\/jats:bold>\n                    , and\n                    <jats:bold>17<\/jats:bold>\n                    ).\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202503702","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T09:31:13Z","timestamp":1773394273000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chemical Constituents of\n                    <i>Taxodium mucronatum<\/i>\n                    (Cupressaceae) and Some of Its Endophytic Fungi, and Their In Silico and In Vitro Evaluations as SARS\u2010CoV\u20102 Inhibitors and as Cytotoxic Agents"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2604-2180","authenticated-orcid":false,"given":"Nadia","family":"Mendoza","sequence":"first","affiliation":[{"name":"Departamento de Ingenier\u00eda Qu\u00edmica Tecnol\u00f3gico Nacional de M\u00e9xico  Celaya Guanajuato M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2260-5904","authenticated-orcid":false,"given":"Olivia","family":"P\u00e9rez\u2010Valera","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica Universidad Nacional Aut\u00f3noma de M\u00e9xico Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0900-6017","authenticated-orcid":false,"given":"Antonio","family":"Nieto\u2010Camacho","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica Universidad Nacional Aut\u00f3noma de M\u00e9xico Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5123-5246","authenticated-orcid":false,"given":"Mar\u00eda Teresa","family":"Ram\u00edrez\u2010Apan","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica Universidad Nacional Aut\u00f3noma de M\u00e9xico Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9267-8991","authenticated-orcid":false,"given":"Marcela Guadalupe","family":"T\u00e9llez\u2010Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Departamento Agroindustrial Universidad de Guanajuato Campus Celaya\u2010Salvatierra  Celaya Guanajuato M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8386-9569","authenticated-orcid":false,"given":"Eleazar M.","family":"Escamilla\u2010Silva","sequence":"additional","affiliation":[{"name":"Departamento de Ingenier\u00eda Qu\u00edmica Tecnol\u00f3gico Nacional de M\u00e9xico  Celaya Guanajuato M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1394-6300","authenticated-orcid":false,"given":"Guillermo","family":"Delgado","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica Universidad Nacional Aut\u00f3noma de M\u00e9xico Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.9b01285"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.9734\/BJPR\/2015\/16293"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.7550\/rmb.32195"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.22201\/ib.20078706e.2011.1.380"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2010.11.055"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378\u20108741(95)01230\u2010B"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2005.04.019"},{"key":"e_1_2_10_9_1","first-page":"7","article-title":"Composici\u00f3n Qu\u00edmica y Actividad Antimicrobiana de los Aceites Esenciales de Hojas de Bursera Graveolens y Taxodium Mucronatum de Chiapas, M\u00e9xico","volume":"69","author":"Luj\u00e1n\u2010Hidalgo M. 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