{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T21:35:28Z","timestamp":1792445728690,"version":"4.5.0"},"reference-count":110,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In recent years, significant progress has been achieved in the synthesis of six\u2010membered N\u2010heterocycle\u2010fused hybrids, particularly derivatives of quinoline, quinazoline, quinoxaline, and isoquinoline linked with triazole rings. These hybrid molecules are predominantly synthesized through efficient click chemistry techniques using variety of copper salts like CuSO\n                    <jats:sub>4<\/jats:sub>\n                    , CuI, Cu(OAc)\n                    <jats:sub>2<\/jats:sub>\n                    , and sodium ascorbate as reducing agent to efficiently link azides and alkynes, facilitating an efficient production of target compounds. N\u2010heterocycles are well\u2010known for their diverse biological activities and their conjugation with triazole moieties has further expanded the potential for discovering novel, potent bioactive agents. This review offers a comprehensive analysis of research advancements in the past 15 years, emphasizing the synthesis, structural diversity, and biological applications of these fused heterocyclic\u2010triazole hybrids. Focus is given to their evaluated biological activities, including antimicrobial, antimalarial, anticancer, antifungal, antiviral, and enzyme inhibition etc., assessed through in vitro assays as well as computational techniques. Significant outcomes indicate strong anticancer effects across multiple cell lines, including HCT\u2010116, MCF\u20107, and HeLa. Along with that, electron\u2010withdrawing groups like fluorine or chlorine significantly enhanced anticancer and antimicrobial activity. Best nine leads were filtered out from various biological activities with IC\n                    <jats:sub>50<\/jats:sub>\n                    values ranging from 0.04 to 3.67\u00a0\u00b5M. The insights presented here highlight the immense therapeutic potential of these compounds and their importance as promising candidates for future drug development, thereby providing a valuable resource for researchers aiming to explore new avenues in bioactive heterocyclic chemistry.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202503719","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T19:14:22Z","timestamp":1776453262000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Biological Applications and Synthesis of 1,2,3\u2010triazole Linked Six Membered Fused N\u2010heterocycles"],"prefix":"10.1002","volume":"23","author":[{"family":"Himani","sequence":"first","affiliation":[{"name":"University School of Basic &amp; Applied Sciences Guru Gobind Singh Indraprastha University  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asmita","family":"Singh","sequence":"additional","affiliation":[{"name":"University School of Basic &amp; Applied Sciences Guru Gobind Singh Indraprastha University  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5282-7216","authenticated-orcid":false,"given":"Pankaj","family":"Khanna","sequence":"additional","affiliation":[{"name":"Department of Chemistry Acharya Narendra Dev College University of Delhi  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep Kumar","family":"Singh","sequence":"additional","affiliation":[{"name":"Jindal Global Business School O.P. 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