{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T13:04:50Z","timestamp":1785330290479,"version":"3.55.0"},"reference-count":43,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Atmospheric pollution contributes to oxidative cellular damage and metabolic disorders due to hepatic metabolism of some toxins. In this study, we evaluated the in vitro antioxidant capacity of\n                    <jats:italic>Pistacia lentiscus<\/jats:italic>\n                    extract. Furthermore, the in vivo anti\u2010inflammatory, antioxidant, and hepatoprotective effects were explored in DMBA\u2010mice model. We also evaluated the systems\u2010level characterization of gene networks associated with environmental response with genes regulated by the AhR\/ARNT and HIF\u20102\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \/ARNT signaling pathways. Our results proved that\n                    <jats:italic>P. lentiscus<\/jats:italic>\n                    presented a rich source of fatty acids and secondary metabolites. In vitro, it demonstrated a strong free radical scavenging capacity with antioxidant effects. In vivo, DMBA exposure altered lipid profiles and CBCC with C\u2010RP content, induced oxidative stress, and disrupted liver and kidney function. Cotreatment with\n                    <jats:italic>P. lentiscus<\/jats:italic>\n                    corrected plasma biochemical parameters, restored the C\u2010RP activity and CBCC levels (C\u2010RP: 0.9 \u00b5g\/dL; WBC: 15.6 \u00d7 10\n                    <jats:sup>9<\/jats:sup>\n                    \/L; Mid: 0.22 \u00d7 10\n                    <jats:sup>9<\/jats:sup>\n                    \/L), reduced lipid peroxidation, and enhanced antioxidant enzyme activities (SOD, CAT, GPx;\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05). Histological analysis confirmed the protective effects of\n                    <jats:italic>P. lentiscus<\/jats:italic>\n                    on liver tissue, preventing steatosis and cellular injury. Network analysis highlighted the central role of the AhR\/ARNT complex and its molecular partners in coordinating xenobiotic metabolism and cellular adaptive responses, revealing a mechanistic basis for P. lentiscus as a promising anti\u2010inflammatory and antioxidant dietary supplement with potential hepatoprotective effect.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202503720","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T10:55:39Z","timestamp":1784199339000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["From Network Analysis to Functional Nutraceutical Protection:\n                    <i>Pistacia lentiscus<\/i>\n                    L. Mitigates DMBA\u2010Induced Liver Damage Through AhR\/ARNT Pathway Regulation"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7073-0250","authenticated-orcid":false,"given":"Omayma","family":"Abidi","sequence":"first","affiliation":[{"name":"Faculty of Sciences of Tunis University Tunis El Manar  Tunis Tunisia"},{"name":"Laboratory of Physiology and Pharmacology National School of Veterinary Medicine, University of Manouba  Ariana Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imen","family":"Hammami","sequence":"additional","affiliation":[{"name":"Laboratory of Population Health, Environmental Aggressors and Alternative Therapies (LR24ES10), Faculty of Medicine of Tunis University of Tunis El Manar Tunis Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariem","family":"Zakraoui","sequence":"additional","affiliation":[{"name":"Faculty of Sciences of Tunis University Tunis El Manar  Tunis Tunisia"},{"name":"Laboratory of Management and Valorization of Forest Resources\u2013National Research Institute of Water, Forests and Rural Engineering University of Carthage  Ariana Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Gressier","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology, Pharmacokinetics and Clinical Pharmacy Faculty of Pharmacy University of Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houcine","family":"Selmi","sequence":"additional","affiliation":[{"name":"Laboratory of Sylvo\u2010Pastorales Resources, Sylvo\u2010Pastoral Institute of Tabarka University of Jendouba  Tabarka Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Eto","sequence":"additional","affiliation":[{"name":"Laboratories TBC, Laboratory of Pharmacology, Pharmacokinetics, and Clinical Pharmacy Faculty of Pharmaceutical and Biological Sciences 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