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However, its water insolubility limits its clinical application. In this study, sodium acacetin was prepared by double decomposition reaction and characterized by differential thermal analysis, ultraviolet\u2010visible spectroscopy, Fourier\u2010transform infrared spectroscopy, inductively coupled plasma\u2010mass spectrometry, and\n                    <jats:sup>1<\/jats:sup>\n                    H nuclear magnetic resonance. In addition, the anti\u2010hepatocellular carcinoma activity of sodium acacetin was investigated by using HepG2 cells and H22 tumor\u2010bearing mice. When acacetin and sodium hydroxide react in a 1:2 molar ratio, they form acacetin monosodium salt and disodium salt in a 1.6:1 ratio. The solubility of the obtained mixed sodium acacetin was about 6000 times higher than that of acacetin. The formation of sodium acacetin was verified by the analysis method mentioned above. Moreover, sodium acacetin significantly inhibited cell proliferation and colony formation, arrested the cell cycle at G0\/G1 phase, and induced apoptosis in HepG2 cells in a dose\u2011dependent manner. It exhibited a more significant antitumor effect than acacetin in H22 tumor\u2010bearing mice. The current study provided a salt\u2010formation strategy to improve the solubility and bioactivity of poorly water\u2010soluble drugs and a possible drug form for further clinical treatment of liver cancer with acacetin.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202503726","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T13:05:14Z","timestamp":1778677514000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Enhancement of the Anti\u2010Hepatoma Activity of Acacetin Through Salt Formation of Sodium Acacetin"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4948-5830","authenticated-orcid":false,"given":"Yufeng","family":"Liu","sequence":"first","affiliation":[{"name":"School of Medicine Anhui University of Science and Technology  Huainan China"},{"name":"Key Laboratory of Industrial Dust Deep Reduction and Occupational Health and 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