{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T12:46:28Z","timestamp":1775997988900,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T00:00:00Z","timestamp":1773446400000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Type 2 Diabetes mellitus is a complex metabolic disorder often accompanied by oxidative stress, obesity, and dyslipidemia. The limitations of current treatments have increased interest in plant\u2010derived compounds with multitarget potential. This study investigates the in vitro antidiabetic, anti\u2010obesity, antihyperlipidemic, and antioxidant activities of ethanol extracts prepared from selected parts of eight plant species collected from various regions of T\u00fcrkiye. Ethanol extracts of selected plant parts were evaluated for their inhibitory effects on \u03b1\u2010glucosidase, \u03b1\u2010amylase, pancreatic lipase, and cholesterol esterase. Antioxidant activities were assessed via DPPH radical scavenging, metal chelating, and ferric reducing power assays. Phytochemical contents were determined using spectrophotometric methods and LC\u2010MS\/MS profiling. Among the tested species,\n                    <jats:italic>Euphorbia macroclada<\/jats:italic>\n                    showed the most pronounced in vitro activity, including potent\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010glucosidase inhibition (IC\n                    <jats:sub>50<\/jats:sub>\n                    : 37.01\u00a0\u00b1\u00a03.37\u00a0\u00b5g\/mL), strong DPPH radical\u2010scavenging activity (89.34%\u00a0\u00b1\u00a00.15%), and notable cholesterol esterase inhibition (IC\n                    <jats:sub>50<\/jats:sub>\n                    : 79.99\u00a0\u00b1\u00a03.48\u00a0\u00b5g\/mL). LC\u2010MS\/MS analysis of\n                    <jats:italic>E. macroclada<\/jats:italic>\n                    revealed a phenolic compound profile, with quinic acid and isoquercitrin as major constituents.\n                    <jats:italic>Olea europaea<\/jats:italic>\n                    (branch) and\n                    <jats:italic>Cichorium intybus<\/jats:italic>\n                    also exhibited notable\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010glucosidase inhibitor and antioxidant activities. To the best of our knowledge,\n                    <jats:italic>Silene vulgaris<\/jats:italic>\n                    var.\n                    <jats:italic>macrocarpa<\/jats:italic>\n                    is reported here for the first time as a mild pancreatic lipase inhibitor, and the\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010glucosidase inhibitory activity of the ethanol extract of\n                    <jats:italic>E. macroclada<\/jats:italic>\n                    is investigated for the first time in this study. Overall, these findings provide preliminary in vitro screening evidence and highlight promising candidates for further investigation; bioactivity\u2010guided fractionation, enzyme kinetic studies, and validation in cellular and\/or in vivo models are required before therapeutic conclusions can be drawn. In this study, Euphorbia macroclada was evaluated for its antidiabetic potential, and the results suggest it may be a promising candidate for further investigation.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202503728","type":"journal-article","created":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T11:00:22Z","timestamp":1773486022000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["LC\u2010MS\/MS Analysis and Preliminary Screening of Antidiabetic, Anti\u2010Obesity, and Antioxidant Activities of Selected Turkish Plants"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2159-9860","authenticated-orcid":false,"given":"Bur\u00e7in","family":"\u00d6z\u00fcpek","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy Gazi University  Ankara Turkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7782-9832","authenticated-orcid":false,"given":"Sultan","family":"Pekacar","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy Gazi University  Ankara Turkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4098-0221","authenticated-orcid":false,"given":"Semih","family":"Bulut","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy Suleyman Demirel University  Isparta Turkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4090-7227","authenticated-orcid":false,"given":"Mustafa Abdullah","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Science and Technology Research and Application Center, Dicle University, Diyarbak\u0131r, Turkiye Dicle University Science and Technology Research and Application Center Diyarbakir Turkiye"},{"name":"Department of Analytical Chemistry Faculty of Pharmacy Dicle University  Diyarbakir Turkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8006-2054","authenticated-orcid":false,"given":"O\u011fuz","family":"\u00c7akir","sequence":"additional","affiliation":[{"name":"Science and Technology Research and Application Center, Dicle University, Diyarbak\u0131r, Turkiye Dicle University Science and Technology Research and Application Center Diyarbakir Turkiye"},{"name":"Department of Nutrition and Dietetics Faculty of Health Sciences Dicle University  Diyarbakir Turkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5196-3892","authenticated-orcid":false,"given":"Abbas","family":"Tarhan","sequence":"additional","affiliation":[{"name":"Science and Technology Research and Application Center, Dicle University, Diyarbak\u0131r, Turkiye Dicle 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