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This situation poses a significant global health challenge. Recent investigations have highlighted that a diverse array of bioactive compounds extracted from medicinal plants plays a critical role in preventing and treating BC by targeting cancer cell proliferation and survival mechanisms. Notably, these bioactive constituents exhibit anticancer activity against both conventional cancer cells and those resistant to standard therapies. Furthermore, the efficacy of these compounds has been substantiated through extensive research involving in vivo animal models and clinical trials, which affirm their potential therapeutic benefits. In addition to exploring the bioactivity of these natural agents, recent advancements in nanotechnology have emerged as a promising strategy to enhance the bioavailability of less soluble anticancer drugs, thereby improving their therapeutic effectiveness. This review aims to consolidate recent findings regarding the medicinal plants and their bioactive constituents in BC treatment, elaborating on their mechanisms of action, potential applications, and future directions in research and clinical practice.<\/jats:p>","DOI":"10.1002\/cbdv.202503746","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T14:56:07Z","timestamp":1781708167000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Medicinal Plants in Breast Cancer Therapy: Ethnopharmacology, Bioactive Compounds, and Drug Discovery"],"prefix":"10.1002","volume":"23","author":[{"given":"Swati","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Biotechnology Delhi Pharmaceutical Sciences and Research University New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srichandan","family":"Padhi","sequence":"additional","affiliation":[{"name":"Department of Biosciences Graphic Era (Deemed to be) University Dehradun Uttarakhand India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neha","family":"Baryah","sequence":"additional","affiliation":[{"name":"Department of Forensic Sciences, Chandigarh School of Business Chandigarh Group of Colleges  Jhanjeri Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangita","family":"Sharma","sequence":"additional","affiliation":[{"name":"G.B. 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