{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T06:37:27Z","timestamp":1791959847996,"version":"4.3.4"},"reference-count":58,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Marine microbial metabolites have long served as valuable sources for drug discovery, exhibiting diverse biological activities, including antiparasitic, antimicrobial, and antiviral effects. Chagas disease (CD), a neglected tropical disease caused by\n                    <jats:italic>Trypanosoma cruzi<\/jats:italic>\n                    , affects approximately 8 million people worldwide. Currently, only two drugs are available for treatment, both associated with significant toxicity, underscoring the urgent need for new therapeutic alternatives. In this context, and considering the remarkable chemical diversity of marine bacteria, the present study investigated the anti\u2010\n                    <jats:italic>T. cruzi<\/jats:italic>\n                    potential of metabolites produced by sediment\u2010 and sponge\u2010associated microbial communities from Buzios Island, Brazil. The sponges were identified as\n                    <jats:italic>Cinachyrella alloclada<\/jats:italic>\n                    and\n                    <jats:italic>Haliclona (Soestella) caerulea<\/jats:italic>\n                    . Using 16S rRNA gene sequencing, nine marine bacterial isolates were identified, belonging to the genera\n                    <jats:italic>Dokdonia<\/jats:italic>\n                    ,\n                    <jats:italic>Vibrio<\/jats:italic>\n                    ,\n                    <jats:italic>Alteromonas<\/jats:italic>\n                    ,\n                    <jats:italic>Planococcus<\/jats:italic>\n                    ,\n                    <jats:italic>Shewanella<\/jats:italic>\n                    ,\n                    <jats:italic>Micrococcus<\/jats:italic>\n                    , and\n                    <jats:italic>Pseudoalteromonas<\/jats:italic>\n                    . The antiparasitic activity of the extracts was evaluated against trypomastigote forms, yielding potent IC\n                    <jats:sub>50<\/jats:sub>\n                    values ranging from 1 to 87 \u00b5g\/mL. Dereplication studies based on\n                    <jats:sup>1<\/jats:sup>\n                    H nuclear magnetic resonance and high\u2010performance liquid chromatography\u2010tandem mass spectrometry analyses of the\n                    <jats:italic>Pseudoalteromonas piscicida<\/jats:italic>\n                    extract revealed putative antitrypanosomal compounds, annotated as alkaloids and polycyclic tetramate macrolactams. Overall, this study demonstrates the high pharmacological potential of marine bacterial strains as sources of drug candidates for CD.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202503749","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T10:58:58Z","timestamp":1770980338000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Unlocking Marine Microbial Metabolites of Sponges and Sediments as a Source of Anti\u2010\n                    <i>Trypanosoma cruzi<\/i>\n                    Compounds"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5778-2545","authenticated-orcid":false,"given":"Vanessa","family":"Albuquerque","sequence":"first","affiliation":[{"name":"Pathophysiology Laboratory Instituto Butantan  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8896-2770","authenticated-orcid":false,"given":"Felipe S.","family":"Sales","sequence":"additional","affiliation":[{"name":"Centre of Natural Sciences and Humanities Universidade Federal do ABC  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7109-9106","authenticated-orcid":false,"given":"Vin\u00edcius Galv\u00e3o","family":"Wakui","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica Universidade Federal de Goi\u00e1s Goi\u00e2nia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1366-0764","authenticated-orcid":false,"given":"Luc\u00edlia","family":"Kato","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica Universidade Federal de Goi\u00e1s Goi\u00e2nia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3658-1372","authenticated-orcid":false,"given":"Ulisses","family":"Pinheiro","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Porifera, Departamento de Zoologia Universidade Federal de Pernambuco, Cidade Universit\u00e1ria Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1193-8374","authenticated-orcid":false,"given":"Jo\u00e3o Henrique G.","family":"Lago","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica Universidade Federal de Goi\u00e1s Goi\u00e2nia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2559-7344","authenticated-orcid":false,"given":"Andre Gustavo","family":"Tempone","sequence":"additional","affiliation":[{"name":"Pathophysiology Laboratory Instituto Butantan  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,13]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.5194\/bg\u20107\u20102851\u20102010"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100042\u2010101353"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.5c00844"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.9b01285"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/agronomy15061350"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1039\/d0np00078g"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph17040499"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules170911146"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/life13030663"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201055302\u20103"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1507574"},{"key":"e_1_2_11_13_1","unstructured":"Marinespecies.Org. 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