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Starting from 2,3,4,9\u2010tetrahydrospiro[1H\u2010carbazole\u20101,2\u2019\u2010[1,3]dithiolan]\u20104(9H)\u2010one\n                    <jats:bold>I<\/jats:bold>\n                    with (1,3\u2010dithiolan\u20102\u2010yl)methanamine, reduction of imine\n                    <jats:bold>II<\/jats:bold>\n                    with NaBH\n                    <jats:sub>4<\/jats:sub>\n                    yielded to the amine and benzoylation, N\u2010((1,3\u2010dithiolan\u20102\u2010yl)methyl)\u2010N\u2010(2,3,4,9\u2010tetrahydrospiro[carbazole\u20101,2'\u2010[1,3]dithiolan]\u20104\u2010yl)benzamide\n                    <jats:bold>III<\/jats:bold>\n                    . Compounds\n                    <jats:bold>IV<\/jats:bold>\n                    and\n                    <jats:bold>V<\/jats:bold>\n                    were completed through several steps from\n                    <jats:bold>III<\/jats:bold>\n                    . The resulting structure\n                    <jats:bold>V<\/jats:bold>\n                    underwent an intramolecular aldol reaction using NaH as a base for the cyclization of 2\u2010benzoyle\u20104\u2010hydroxy\u20101,2,3,4,5,7\u2010hexehydro\u20101,5\u2010methanoazocino[4,3\u2010\n                    <jats:italic>b<\/jats:italic>\n                    ]indole\u20106\u2010one\n                    <jats:bold>VI<\/jats:bold>\n                    , which represents the tetracyclic skeleton of\n                    <jats:italic>Strychnos<\/jats:italic>\n                    alkaloids. Besides, quantum chemical computations were conducted on compounds\n                    <jats:bold>I\u2013VI<\/jats:bold>\n                    . Regarding structural parameters and spectroscopic characterization, the experimental and computational data were found to be in good agreement. Also, ADMET, bioavailability, and drug\u2010likeness properties of the data set were determined to provide comprehensive information on structure\u2010activity relationships. The interactions of\n                    <jats:bold>I\u2013VI<\/jats:bold>\n                    against DNA gyrase of\n                    <jats:italic>E. coli<\/jats:italic>\n                    , CYP51 from\n                    <jats:italic>Candida glabrata<\/jats:italic>\n                    , and leukemia inhibitory factor were evaluated with molecular docking for foresight into the possible bioactivities. This comprehensive work hopefully to provide the structural, physical, and chemical properties, which would be important to optimizing the related properties of the molecular systems for biomedical purposes.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202503759","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T19:06:06Z","timestamp":1771268766000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Synthesis of Novel Tetracyclic Azocino[4,3\u2010b]Indole Framework: Combined Spectroscopic, DFT, Molecular Docking, and ADMET Analysis"],"prefix":"10.1002","volume":"23","author":[{"given":"Nesimi","family":"Uludag","sequence":"first","affiliation":[{"name":"Faculty of Arts and Sciences, Department of Chemistry Nam\u0131k Kemal University  Tekirda\u011f 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