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The enantiomeric mixtures\n                    <jats:bold>1<\/jats:bold>\n                    \u2013\n                    <jats:bold>6<\/jats:bold>\n                    were resolved into their corresponding enantiomers (\n                    <jats:bold>1a<\/jats:bold>\n                    \/\n                    <jats:bold>1b<\/jats:bold>\n                    \u2013\n                    <jats:bold>6a<\/jats:bold>\n                    \/\n                    <jats:bold>6b<\/jats:bold>\n                    ) by chiral column chromatography. The structures were elucidated by comprehensive spectroscopic analyses, and the absolute configurations were determined by quantum chemical calculations of electronic circular dichroism. Among them, compound\n                    <jats:bold>3a<\/jats:bold>\n                    demonstrated cardioprotective effects, increasing H9c2 cell viability under oxygen\u2010glucose deprivation and decreasing brain natriuretic peptide messenger RNA (mRNA) levels. In addition, compound\n                    <jats:bold>3a<\/jats:bold>\n                    suppressed transforming growth factor\u2010\u03b2 mRNA in angiotensin II (Ang II)\u2010stimulated cardiac fibroblasts, indicating a potential to attenuate myocardial fibrosis.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202503780","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T07:42:15Z","timestamp":1766994135000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["New Phthalide Derivatives With Cardioprotective Effects From the Marine Fungus\n                    <i>Diaporthe phaseolorum<\/i>\n                    HZ\u20102"],"prefix":"10.1002","volume":"23","author":[{"given":"Ran\u2010Qi","family":"Feng","sequence":"first","affiliation":[{"name":"State Key Laboratory of Chemical Biology Shanghai Institute of Materia Medica, Chinese Academy of Sciences  Shanghai China"},{"name":"Shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute For Drug Discovery  Yantai China"},{"name":"University of Chinese Academy of Sciences  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan\u2010Qiu","family":"Hu","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica Nanjing University of Chinese Medicine  Nanjing China"},{"name":"Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences  Zhongshan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin\u2010Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute For Drug Discovery  Yantai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Gao","sequence":"additional","affiliation":[{"name":"Shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute For Drug Discovery  Yantai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han\u2010Bin","family":"Lin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemical Biology Shanghai Institute of Materia Medica, Chinese Academy of Sciences  Shanghai China"},{"name":"University of Chinese Academy of Sciences  Beijing China"},{"name":"School of Chinese Materia Medica Nanjing University of Chinese Medicine  Nanjing China"},{"name":"Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences  Zhongshan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7919-9726","authenticated-orcid":false,"given":"Xu\u2010Wen","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemical Biology Shanghai Institute of Materia Medica, Chinese Academy of Sciences  Shanghai China"},{"name":"Shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute For Drug Discovery  Yantai China"},{"name":"University of Chinese Academy of Sciences  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.11.005"},{"key":"e_1_2_9_3_1","first-page":"e41","article-title":"2025 Heart Disease and Stroke Statistics: A Report of US and Global Data from the American Heart Association","volume":"8","author":"Martin S. 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