{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T09:09:14Z","timestamp":1788858554026,"version":"build-2803163510"},"reference-count":58,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Ultraviolet B (UVB) radiation induces oxidative stress and inflammation, leading to skin damage and related disorders.\n                    <jats:italic>Tinospora cordifolia<\/jats:italic>\n                    , a medicinal plant rich in bioactive phytoconstituents with reported antioxidant and anti\u2010inflammatory properties, was used in this study to develop bovine serum albumin (BSA)\u2010based hydrogels encapsulating aqueous and hydroalcoholic extracts of\n                    <jats:italic>T. cordifolia<\/jats:italic>\n                    . The protective effects of these hydrogels were evaluated against UVB\u2010induced skin inflammation in golden hamsters. The formulations were characterized using rheology, Fourier\u2010transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM) to assess physicochemical properties. Rheological analysis confirmed the hydrogel's viscoelastic nature. FTIR spectra showed successful encapsulation of the extract, indicated by interactions of characteristic functional groups. SEM imaging revealed a porous network structure of the hydrogel, indicating successful formation of the BSA\u2010based matrix. Biological efficacy was assessed by measuring skin edema, antioxidant activity (SOD and catalase), and pro\u2010inflammatory cytokines (IL\u20101\u03b2, IL\u20106, TNF\u2010\u03b1). Histology showed reduced epidermal thickening, inflammation, and tissue damage in treated skin. The hydrogels significantly reduced UVB\u2010induced edema, increased antioxidant enzyme levels, and decreased cytokine levels. Western blot analysis showed downregulation of NF\u2010\u03baB, COX\u20102, and p53, and upregulation of Bcl\u20102. These findings suggest that\n                    <jats:italic>T. cordifolia<\/jats:italic>\n                    \u2010loaded hydrogels offer a promising natural formulation for alleviating UVB\u2010induced skin inflammation and oxidative damage.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202503784","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:47:53Z","timestamp":1786988873000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Topical\n                    <i>Tinospora cordifolia<\/i>\n                    BSA Hydrogel Formulation Attenuates UVB\u2010Induced Skin Inflammation in Golden Hamsters"],"prefix":"10.1002","volume":"23","author":[{"given":"Nitesh Kumar","family":"Mishra","sequence":"first","affiliation":[{"name":"Department of Zoology Institute of Science Banaras Hindu University  Varanasi Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shikha","family":"Tripathi","sequence":"additional","affiliation":[{"name":"Department of Physics Indian Institute of Technology (Banaras Hindu University)  Varanasi Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soumya Ranjan","family":"Mohanty","sequence":"additional","affiliation":[{"name":"Department of Zoology Institute of Science Banaras Hindu University  Varanasi Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khushi","family":"Gusain","sequence":"additional","affiliation":[{"name":"Department of Zoology Institute of Science Banaras Hindu University  Varanasi Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avanish Singh","family":"Parmar","sequence":"additional","affiliation":[{"name":"Department of Physics Indian Institute of Technology (Banaras Hindu University)  Varanasi Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2724-7284","authenticated-orcid":false,"given":"Sanjeev Kumar","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Zoology Institute of Science Banaras Hindu University  Varanasi Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandana","family":"Haldar","sequence":"additional","affiliation":[{"name":"Department of Zoology Institute of Science Banaras Hindu University  Varanasi Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20104632.2004.02186.x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.4161\/derm.20013"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14033"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20061435"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600\u20100781.2002.180307.x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms140612222"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2019.08.003"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.06.033"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/d3ra08178h"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.2147\/NSA.S19419"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.4103\/0257\u20107941.107344"},{"key":"e_1_2_11_13_1","first-page":"50","article-title":"Tinospora cordifolia: Its Bioactivities & Evaluation of Physicochemical Properties","volume":"2","author":"Meena A. 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