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This study examined the protective effects and underlying mechanisms of\n                    <jats:italic>G. indica<\/jats:italic>\n                    hydroalcoholic extract (GIE) against OLZ\u2010induced cardiometabolic alterations using\n                    <jats:italic>in vitro<\/jats:italic>\n                    and computational approaches. GIE significantly reduced OLZ\u2010induced cytotoxicity in H9c2(2\u20101) cardiomyocytes by lowering lactate dehydrogenase (LDH), creatine kinase\u2010MB (CK\u2010MB), and nitric oxide (NO) levels, while enhancing glucose utilization. Gene expression analysis showed downregulation of IL6, BAX, CASP3, and CAMK2B, alongside upregulation of BCL2, indicating anti\u2010inflammatory and anti\u2010apoptotic modulation. Network pharmacology and\n                    <jats:italic>in silico<\/jats:italic>\n                    analyses identified thirteen phytocompounds targeting 35 CMD\u2010related proteins, with gambogic acid\u2010 RAGE and amentoflavone\u2010 CALM1 interactions demonstrating the strongest binding affinities, supported by docking and molecular dynamics simulations. Overall, GIE exhibits multi\u2010target regulatory effects on oxidative, inflammatory, and metabolic pathways, suggesting its therapeutic potential in mitigating OLZ\u2010induced cardiometabolic disturbances. The current findings indicate promising mechanistic potential of GIE against OLZ\u2010 induced cardiometabolic alterations, warranting further validation through\n                    <jats:italic>in vivo<\/jats:italic>\n                    and clinical studies.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202503806","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T10:55:59Z","timestamp":1784199359000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multi\u2010Target Cardioprotective Potential of\n                    <i>Garcinia indica<\/i>\n                    Choisy in Olanzapine\u2010Induced Cardiometabolic Dysregulation: Evidence From Computational and Experimental Insights in H9c2(2\u20101) Cells"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9464-3899","authenticated-orcid":false,"given":"Faizan 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