{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:10:17Z","timestamp":1792195817024,"version":"4.4.0"},"reference-count":60,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study comparatively characterized the phenolic profiles and in vitro cytotoxic activity of methanolic extracts from aerial and underground parts of eight\n                    <jats:italic>Geranium<\/jats:italic>\n                    species native to Serbia (\n                    <jats:italic>Geranium macrorrhizum<\/jats:italic>\n                    ,\n                    <jats:italic>Geranium robertianum<\/jats:italic>\n                    ,\n                    <jats:italic>Geranium phaeum<\/jats:italic>\n                    ,\n                    <jats:italic>Geranium sanguineum<\/jats:italic>\n                    ,\n                    <jats:italic>Geranium<\/jats:italic>\n                    <jats:italic>palustre<\/jats:italic>\n                    ,\n                    <jats:italic>Geranium pyrenaicum<\/jats:italic>\n                    ,\n                    <jats:italic>Geranium columbinum<\/jats:italic>\n                    , and\n                    <jats:italic>Geranium lucidum<\/jats:italic>\n                    ). Phenolic constituents were analysed by LC\u2010PDA\/MS, and cytotoxicity against human cancer cell lines (HeLa, PC\u20103, HT\u201029, Hs\u2010294T) and normal lung fibroblasts (MRC\u20105) was evaluated using the MTT assay. Ellagitannins predominated, followed by phenolic acids and flavonols, with pronounced species\u2010 and organ\u2010specific variability. Some phenolics were identified for the first time in specific taxa and organs. Several extracts showed selective cytotoxicity, mainly against HeLa cells, with the strongest activity observed for underground parts of\n                    <jats:italic>G. sanguineum<\/jats:italic>\n                    (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 2.52\u00a0\u00b5g\/mL). Geraniin demonstrated selective cytotoxic effects. These findings highlight the chemical diversity and biological potential of the investigated\n                    <jats:italic>Geranium<\/jats:italic>\n                    species and support further mechanistic and in vivo studies.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202503814","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T06:01:51Z","timestamp":1775800911000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Phenolic Profiles and Cytotoxic Activities of Methanolic Extracts From Eight\n                    <i>Geranium<\/i>\n                    L. Species"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1867-2537","authenticated-orcid":false,"given":"Milan","family":"Ili\u0107","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy University of Business Academy in Novi Sad Novi Sad Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8663-6680","authenticated-orcid":false,"given":"Stevan","family":"Samard\u017ei\u0107","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy University of Belgrade\u2010Faculty of Pharmacy  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2399-0807","authenticated-orcid":false,"given":"Vesna","family":"Koji\u0107","sequence":"additional","affiliation":[{"name":"Oncology Institute of Vojvodina Faculty of Medicine University of Novi Sad  Sremska Kamenica Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1747-4718","authenticated-orcid":false,"given":"Dimitar","family":"Jakimov","sequence":"additional","affiliation":[{"name":"Oncology Institute of Vojvodina Faculty of Medicine University of Novi Sad  Sremska Kamenica Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8882-8862","authenticated-orcid":false,"given":"Mirjana","family":"Mar\u010deti\u0107","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy University of Belgrade\u2010Faculty of Pharmacy  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2367-568X","authenticated-orcid":false,"given":"Milica","family":"Drobac","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy University of Belgrade\u2010Faculty of Pharmacy  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28041845"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom10020221"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6475624"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612826666200114110323"},{"key":"e_1_2_10_6_1","first-page":"134","volume-title":"Flora SR Srbije","author":"Jankovi\u0107 M.","year":"1973"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants14060918"},{"key":"e_1_2_10_8_1","volume-title":"Le\u010denje Biljem","author":"Tucakov J.","year":"1997"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2010.09.008"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.01020"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eujim.2019.02.007"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0305-1978(99)00060-5"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1515\/znc-2006-7-807"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2024.103940"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants14203190"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202401619"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6FO01075J"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7FO00881C"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph18010039"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22147621"},{"key":"e_1_2_10_21_1","unstructured":"G.Grigoraviciute P. R.Venskutonis A.Cifuentes E.Ib\u00e1\u00f1ez andG.\u00c1lvarez\u2010Rivera \u201cPressurized Liquid Extraction forGeranium MacrorrhizumLeaves Residue Valorization and Phytochemical Characterization by HPLC\u2010UV\u2010MS\/MS \u201d inIX Reuni\u00f3n de Expertos en Tecnolog\u00edas de Fluidos Comprimidos(Asociaci\u00f3n de Expertos en Fluidos Comprimidos 2018)."},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2017.07.016"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00217-003-0836-7"},{"key":"e_1_2_10_24_1","first-page":"70","article-title":"HPLC Study on some Polyphenols of Geranium Macrorrhizum L. (Geraniaceae)","volume":"2","author":"Fodorea C. S.","year":"2004","journal-title":"Ovidius University Annals of Medical Science\u2014Pharmacy"},{"key":"e_1_2_10_25_1","first-page":"174","article-title":"Preliminary HPLC Study on some Polyphenols of Geranium robertianum L. (Geraniaceae)","volume":"109","author":"Fodorea C. S.","year":"2005","journal-title":"Revista Medico\u2010Chirurgicala A Societatii De Medici Si Naturalisti Din Iasi"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15051561"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10600-005-0161-4"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/scipharm88040045"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2017.11.015"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/10826070500295211"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.24271\/psr.01"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-960097"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1095\u20108339.1984.tb00998.x"},{"key":"e_1_2_10_34_1","first-page":"71","volume-title":"Methods in Plant Biochemistry: Assays for Bioactivity","author":"Suffness M.","year":"1991"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arabjc.2013.09.028"},{"key":"e_1_2_10_36_1","first-page":"53","article-title":"Antioxidant Activity and Cytotoxicity of Methanol Extracts of Geranium macrorrhizum and Chemical Composition of Its Essential Oil","volume":"5","author":"Sharopov F.","year":"2017","journal-title":"Journal of Medicinally Active Plants"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/mutage\/gey016"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.3109\/15376516.2016.1139025"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.21929"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-2013-0140"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2015.06.093"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2004.06.004"},{"key":"e_1_2_10_43_1","first-page":"359","article-title":"IGF\u2010II Down Regulation Associated Cell Cycle Arrest in Colon Cancer Cells Exposed to Phenolic Antioxidant Ellagic Acid","volume":"21","author":"Narayanan B. A.","year":"2001","journal-title":"Anticancer Research"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2005.09.004"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-014-2257-2"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2017.3843"},{"key":"e_1_2_10_47_1","first-page":"29","article-title":"Ellagic Acid Induces HeLa Cell Apoptosis via Regulating STAT3 Signaling","volume":"16","author":"Li L. W.","year":"2018","journal-title":"Experimental and Therapeutic Medicine"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10637-005-5856-7"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1995-7645(11)60144-2"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002400100213"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.4081\/dr.2011.e36"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2014.956246"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2016.5335"},{"key":"e_1_2_10_54_1","first-page":"6283","article-title":"Polyphenol\u2010Rich Extracts of Geranium L. Species as Potential Natural Antioxidant and Antimicrobial Agents","volume":"25","author":"Ili\u0107 M.","year":"2021","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.7b00918"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2012.04.017"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/pca.2412"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/925824"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2005.09.024"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2017.11.013"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(83)90303-4"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202503814","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbdv.202503814","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202503814","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T15:47:08Z","timestamp":1785340028000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.202503814"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":60,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/cbdv.202503814"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.202503814","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"2025-11-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e03814"}}