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The animals (6 animals\/group) were divided into: vehicle (2% DMSO), 5\u2010fluorouracil (5\u2010FU) and groups receiving ISO (10, 50, or 100\u00a0mg\/kg). ISO at 100\u00a0mg\/kg (ISO\u2010100) (232.5 \u00b1 3.8\u00a0\u00b5m) attenuated the reduction in villus height induced by 5\u2010FU (125.3 \u00b1 1.5\u00a0\u00b5m) and the reduction in crypt depth in the intestine (ISO\u2010100: 101.7 \u00b1 3.5\u00a0\u00b5m vs 5\u2010FU: 70.8 \u00b1 1.6\u00a0\u00b5m; p &lt; 0.05). The jejunum was chosen for assays involving oxidative stress and inflammation. ISO\u2010100 attenuated the mastocytosis (ISO\u2010100: 7.6 \u00b1 0.1 mast cells\/field vs 5\u2010FU: 12.5 \u00b1 0.2 mast cells\/field;\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05) and goblet cell depletion (ISO\u2010100: 11.0 \u00b1 0.5 cells\/field vs 5\u2010FU: 8.0 \u00b1 0.6 cells\/field;\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05). The treatment with ISO\u2010100 showed lower levels of MDA and MPO, and increased GSH levels. Administration of celecoxib (selective COX\u20102 inhibitor) + ISO\u2010100 increased the villus height and the immunohistochemistry showed that ISO\u2010100 + CLX (7.4% \u00b1 0.1%) attenuates the expression of COX\u20102 in jejunum induced by 5\u2010FU (22.5% \u00b1 0.1%). These results show that ISO\u2010100 attenuates 5\u2010FU\u2010induced intestinal mucositis by modulating the inflammatory process and reducing oxidative stress.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202503827","type":"journal-article","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T13:29:23Z","timestamp":1776950963000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Isoquercitrin Alleviates 5\u2010Fluorouracil\u2010Induced Intestinal Mucositis in Mice by Modulating Inflammation and Oxidative Stress"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5303-9142","authenticated-orcid":false,"given":"L\u00e1zaro de Sousa","family":"Fideles","sequence":"first","affiliation":[{"name":"Center For Studies in Microscopy and Image Processing, Faculty of Medicine, Department of Morphology Federal University of Cear\u00e1 Porangabu\u00e7u Campus  Fortaleza Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0286-1974","authenticated-orcid":false,"given":"Matheus da Silva","family":"Campelo","sequence":"additional","affiliation":[{"name":"Laboratory of Polymers and Materials Innovation, Center of Sciences, Department of Organic and Inorganic Chemistry Federal University of Cear\u00e1 Pici Campus  Fortaleza Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2678-8188","authenticated-orcid":false,"given":"Jo\u00e3o Francisco C\u00e2mara","family":"Neto","sequence":"additional","affiliation":[{"name":"Laboratory of Polymers and Materials Innovation, Center of Sciences, Department of Organic and Inorganic Chemistry Federal University of Cear\u00e1 Pici Campus  Fortaleza Cear\u00e1 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