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Such a disease is considered the most common cause of dementia and affects a large portion of the elderly population worldwide. Currently, cholinesterase inhibitors are used to reduce the symptoms and rate of progression of this disease. Thus, the present study evaluated the acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities of a set of 22\n                    <jats:italic>p<\/jats:italic>\n                    \u2010coumarate derivatives using the spectrophotometric method. The inhibitory activity of the compounds against AChE and BChE was measured using the adapted Ellman spectrophotometric method; the reported inhibition percentages were determined at a final concentration of 100\u00a0\u00b5M. The structures of the synthesized compounds were characterized by FTIR,\n                    <jats:sup>1<\/jats:sup>\n                    H\u2010NMR,\n                    <jats:sup>13<\/jats:sup>\n                    C\u2010NMR, and HRMS spectroscopy. Among the compounds tested, three showed moderate inhibitory activity against AChE and good activity against BChE: (\n                    <jats:italic>E<\/jats:italic>\n                    )\u20104\u2010chlorobenzyl 3\u2010(4\u2010hydroxyphenyl)acrylate (\n                    <jats:bold>14<\/jats:bold>\n                    ) (56.36%; 75.17%), (\n                    <jats:italic>E<\/jats:italic>\n                    )\u20104\u2010bromobenzyl 3\u2010(4\u2010hydroxyphenyl)acrylate (\n                    <jats:bold>15<\/jats:bold>\n                    ) (61.11%; 76.09%), and (\n                    <jats:italic>E<\/jats:italic>\n                    )\u2010naphthalene 3\u2010(4\u2010hydroxyphenyl)acrylate (\n                    <jats:bold>18<\/jats:bold>\n                    ) (59.18%; 65.39%), respectively. Compound\n                    <jats:bold>15<\/jats:bold>\n                    had an IC\n                    <jats:sub>50<\/jats:sub>\n                    of 22.22 \u00b11.50\u00a0mM against BChE, which is notably better than galantamine's BChE inhibition. The in silico analysis suggested that compounds\n                    <jats:bold>14<\/jats:bold>\n                    ,\n                    <jats:bold>15<\/jats:bold>\n                    , and\n                    <jats:bold>18<\/jats:bold>\n                    interact with AChE and BChE. Thus,\n                    <jats:italic>p<\/jats:italic>\n                    \u2010coumaric acid derivatives represent promising prototypes for the search for new drug candidates for the treatment of AD.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202503857","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T07:07:36Z","timestamp":1775027256000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis of\n                    <i>p<\/i>\n                    \u2010Coumarates With Potential Anti\u2010Alzheimer's Action: Enzyme Inhibition and In Silico Studies"],"prefix":"10.1002","volume":"23","author":[{"given":"Susiany Pereira","family":"Lopes","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences Federal University of Para\u00edba  Jo\u00e3o Pessoa Para\u00edba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremias Justo","family":"Em\u00eddio","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Federal University of Para\u00edba  Jo\u00e3o Pessoa Para\u00edba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allana Brunna Sucupira","family":"Duarte","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Federal University of Para\u00edba  Jo\u00e3o Pessoa Para\u00edba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilkay Erdogan","family":"Orhan","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Department of Pharmacognosy Lokman Hekim University  Ankara T\u00fcrkiye"},{"name":"Inovabella Biotechnology and R&amp;D Industry and Trade Corp., LHUSTEK  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma Sezer Senol","family":"Deniz","sequence":"additional","affiliation":[{"name":"Inovabella Biotechnology and R&amp;D Industry and Trade Corp., LHUSTEK  Ankara T\u00fcrkiye"},{"name":"Faculty of Pharmacy Department of Pharmacognosy Gazi University  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramin Ekhteiari","family":"Salmas","sequence":"additional","affiliation":[{"name":"Department of Chemistry Britannia House, King's College  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dami\u00e3o Pergentino","family":"de Sousa","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Federal University of Para\u00edba  Jo\u00e3o Pessoa Para\u00edba 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