{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T12:47:06Z","timestamp":1775998026109,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The anticandidal activity of\n                    <jats:italic>Monotes kerstingii<\/jats:italic>\n                    leaf and root crude extracts was evaluated against five clinical Candida isolates:\n                    <jats:italic>C. albicans<\/jats:italic>\n                    ,\n                    <jats:italic>C. parapsilosis<\/jats:italic>\n                    ,\n                    <jats:italic>C. krusei<\/jats:italic>\n                    ,\n                    <jats:italic>C. glabrata<\/jats:italic>\n                    and\n                    <jats:italic>C. tropicalis<\/jats:italic>\n                    . Extracts from both organs displayed Minimal Inhibitory Concentrations (MICs) ranging from 3.9 to 2000\u00a0\u00b5g\/mL. Out of the five Candida species, the leaf hydroethanolic extract (EMKL) was the most active with MIC values of 3.9, 15.6 and 31.5\u00a0\u00b5g\/mL on\n                    <jats:italic>C. krusei, C. parapsilosis<\/jats:italic>\n                    and\n                    <jats:italic>C. albicans<\/jats:italic>\n                    , respectively. The chemical investigation of these extracts led to the characterization of six previously undescribed metabolites, including a glycosylated stilbene: kerstingioside (\n                    <jats:bold>1<\/jats:bold>\n                    ), three\n                    <jats:italic>cis<\/jats:italic>\n                    stilbene\u2010coumarins:\n                    <jats:italic>cis<\/jats:italic>\n                    \u2010kerstilbcoumarin A\u2013C (\n                    <jats:bold>2\u20134<\/jats:bold>\n                    ) among which two as inseparable\n                    <jats:italic>cis<\/jats:italic>\n                    \/\n                    <jats:italic>trans<\/jats:italic>\n                    \u2010mixtures, one flavanone: kerstingiiflavanone (\n                    <jats:bold>5<\/jats:bold>\n                    ) and one fatty acid glycoside, monestoside B (\n                    <jats:bold>6<\/jats:bold>\n                    ), alongside with 22 known compounds. The distribution of the annotated metabolites in the roots and leaves was confirmed by comprehensive RP\u2010UHPLC\u2010Orbitrap\u2010MS and MS\/MS analysis. In addition, all the isolated compounds were screened for their anticandidal activity. Stilbene\n                    <jats:bold>7<\/jats:bold>\n                    was the most active constituent, with MICs of 7.8, 15.6, and 15.6\u00a0\u00b5g\/mL against\n                    <jats:italic>C. albicans<\/jats:italic>\n                    ,\n                    <jats:italic>C. krusei<\/jats:italic>\n                    , and\n                    <jats:italic>C. parapsilosis<\/jats:italic>\n                    , respectively, while compounds\n                    <jats:bold>14<\/jats:bold>\n                    and\n                    <jats:bold>15<\/jats:bold>\n                    exhibited only moderate activity.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71026","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:00:17Z","timestamp":1772989217000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Isolation, RP\u2010UHPLC\u2010ESI\u2010LIT\u2010Orbitrap\u2010MS\/MS\u2010Based Metabolic Profiling and Anticandidal Activity of the Root and Leaf Secondary Metabolites of\n                    <i>Monotes Kerstingii<\/i>\n                    Gilg (Dipterocarpaceae)"],"prefix":"10.1002","volume":"23","author":[{"given":"Sorelle Kache","family":"Fotsing","sequence":"first","affiliation":[{"name":"Department of Organic Chemistry Faculty of Science University of Yaound\u00e9 1  Yaound\u00e9 Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Ngnintedo","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry Faculty of Science University of Yaound\u00e9 1  Yaound\u00e9 Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanick Kevin Dongmo","family":"Melogmo","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Faculty of Science University of Yaound\u00e9 1  Yaound\u00e9 Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alena","family":"Soboleva","sequence":"additional","affiliation":[{"name":"Department of Bioorganic Chemistry Leibniz Institute of Plant Biochemistry  Halle (Saale) Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevine Dongmo","family":"Jumeta","sequence":"additional","affiliation":[{"name":"Department of Chemistry Higher Teacher Training College University of Yaound\u00e9 1  Yaound\u00e9 Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno Ndjakou","family":"Lenta","sequence":"additional","affiliation":[{"name":"Department of Chemistry Higher Teacher Training College University of Yaound\u00e9 1  Yaound\u00e9 Cameroon"},{"name":"Department of Organic Chemistry Faculty of Science University of Bielefeld  Bielefeld 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