{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T12:47:05Z","timestamp":1775998025230,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Two undescribed sesquiterpene lactones, tithdiverolides A and B (\n                    <jats:bold>1<\/jats:bold>\n                    and\n                    <jats:bold>2<\/jats:bold>\n                    ), and a rare meroterpene lactone, tithdiverolide C (\n                    <jats:bold>3<\/jats:bold>\n                    ), as well as seven known sesquiterpenoids (\n                    <jats:bold>4<\/jats:bold>\n                    \u2212\n                    <jats:bold>7<\/jats:bold>\n                    ) and monoterpenoids (\n                    <jats:bold>8<\/jats:bold>\n                    \u2212\n                    <jats:bold>10<\/jats:bold>\n                    ), were obtained from\n                    <jats:italic>Tithonia diversifolia<\/jats:italic>\n                    (Asteraceae). Structural identification of these compounds relied on a synergistic combination of spectroscopic and computational methods, including NMR, HRESIMS, GIAO NMR calculations with DP4+ probability analysis, and ECD calculations. Chemically, compounds\n                    <jats:bold>1<\/jats:bold>\n                    and\n                    <jats:bold>2<\/jats:bold>\n                    were eudesmane and cadinane sesquiterpene lactones, respectively, while compound\n                    <jats:bold>3<\/jats:bold>\n                    was a rare meroterpene lactone possessing monoterpenoid\u2010methyl ketone hybrid. Biologically, compound\n                    <jats:bold>3<\/jats:bold>\n                    exhibited NO inhibitory activity with an IC\n                    <jats:sub>50<\/jats:sub>\n                    of 33.5 \u00b1 1.3\u00a0\u00b5M.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71090","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T11:40:06Z","timestamp":1773315606000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tithdiverolides A\u2212C, New Terpene Lactones from\n                    <i>Tithonia diversifolia<\/i>"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-4869-658X","authenticated-orcid":false,"given":"Yuan","family":"Wang","sequence":"first","affiliation":[{"name":"Key Laboratory of Marine Genetic Resources Third Institute of Oceanography Ministry of Natural Resources  Xiamen 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