{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T13:31:19Z","timestamp":1789738279603,"version":"4.0.1"},"reference-count":52,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T00:00:00Z","timestamp":1773446400000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Pholiota gallica<\/jats:italic>\n                    is a rarely documented macrofungus, and little is known about its chemical composition and biological potential. This study provides an integrated morphological, molecular, and chemical characterization of\n                    <jats:italic>P. gallica<\/jats:italic>\n                    collected from Constantine, Algeria, along with phylogenetic analysis and an in silico evaluation of its antioxidant and anti\u2010inflammatory activities. Macroscopic observations revealed caps 3\u20138\u00a0cm in diameter, initially viscid, with adnate to slightly emarginate gills and rust\u2010brown spore prints. Molecular analysis based on ITS rDNA confirmed the specimens as\n                    <jats:italic>P. gallica<\/jats:italic>\n                    , forming a well\u2010supported clade with reference strains and clearly separated from closely related species. Chemical profiling showed a predominance of esters and terpenes, with 2,2,4\u2010trimethylpentanediol\u20101,3\u2010diisobutyrate (31.7%), 3\u2010methylapopinene (19.2%), and 2,9\u2010dimethyldecane (14.5%) as major components. The fatty acid profile was rich in unsaturated acids, particularly linoleic acid (44.8%) and oleic acid (33.1%), known for their antioxidant, anti\u2010inflammatory, and antimicrobial properties. Molecular docking studies demonstrated strong binding interactions of these compounds with XO, MPO, 5\u2010LOX, COX\u20102, and iNOS, suggesting their contribution to the bioactivity of\n                    <jats:italic>P. gallica<\/jats:italic>\n                    . These findings provide a solid foundation for future experimental studies and highlight the pharmacological potential of this macrofungus.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71091","type":"journal-article","created":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T11:01:48Z","timestamp":1773486108000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Integrated Morphological, Molecular, and Chemical Characterization of the Macrofungus\n                    <i>Pholiota Gallica<\/i>\n                    With Phylogenetic Analysis and in Silico Antioxidant and Anti\u2010Inflammatory Evaluation"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4420-4374","authenticated-orcid":false,"given":"Roukia","family":"Zatout","sequence":"first","affiliation":[{"name":"Department of Microbial Biotechnology Faculty of Natural and Life Science University of Blida 1  Blida Algeria"},{"name":"Laboratoire De Mycologie De Biotechnologie Et De L'activit\u00e9 Microbienne (LaMyBAM) D\u00e9partement De Biologie Appliqu\u00e9e Universit\u00e9 Des Fr\u00e8res Mentouri  Constantine Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ouided","family":"Benslama","sequence":"additional","affiliation":[{"name":"Department of Natural and Life Sciences Faculty of Exact Sciences and Natural and Life Sciences Larbi Ben M'Hidi University  Oum El Bouaghi Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noreddine Kacem","family":"Chaouche","sequence":"additional","affiliation":[{"name":"Laboratoire De Mycologie De Biotechnologie Et De L'activit\u00e9 Microbienne (LaMyBAM) D\u00e9partement De Biologie Appliqu\u00e9e Universit\u00e9 Des Fr\u00e8res Mentouri  Constantine Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhua","family":"Lu","sequence":"additional","affiliation":[{"name":"Center For Yunnan Plateau Biological Resources Protection and Utilization &amp;Ampyunnan International Joint Laboratory of Fungal Sustainable Utilization in South and Southeast Asia College of Biology and Food Engineering Qujing Normal University  Qujing P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha C.","family":"Karunarathna","sequence":"additional","affiliation":[{"name":"Center For Yunnan Plateau Biological Resources Protection and Utilization &amp;Ampyunnan International Joint Laboratory of Fungal Sustainable Utilization in South and Southeast Asia College of Biology and Food Engineering Qujing Normal University  Qujing P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8535-0533","authenticated-orcid":false,"given":"Stefania","family":"Garzoli","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Technologies of Drug Sapienza University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1201\/9781003335771"},{"key":"e_1_2_9_3_1","unstructured":"R.Zatout N. 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