{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T12:46:29Z","timestamp":1775997989316,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T00:00:00Z","timestamp":1773619200000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82104020"],"award-info":[{"award-number":["82104020"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Two previously undescribed sesquiterpenoid\u2010benzaldehyde hybrids, aquisinoids A (\n                    <jats:bold>1<\/jats:bold>\n                    ) and B (\n                    <jats:bold>2<\/jats:bold>\n                    ), were isolated from agarwood of\n                    <jats:italic>Aquilaria sinensis<\/jats:italic>\n                    . Their structures were elucidated by comprehensive spectroscopic data analysis, single\u2010crystal x\u2010ray diffraction, and electronic circular dichroism calculations. Structurally, both compounds feature a polycyclic core formed by connecting a prezizaane\u2010type sesquiterpenoid unit with a\n                    <jats:italic>p<\/jats:italic>\n                    \u2010hydroxybenzaldehyde moiety via a 1,3\u2010dioxolane bridge. Compounds\n                    <jats:bold>1<\/jats:bold>\n                    and\n                    <jats:bold>2<\/jats:bold>\n                    exhibited moderate inhibition on nitric oxide (NO) production in lipopolysaccharide (LPS)\u2010induced RAW 264.7 macrophages, with\n                    <jats:italic>IC<\/jats:italic>\n                    <jats:sub>50<\/jats:sub>\n                    values of 22.4 and 26.7 \u00b5M, respectively.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71113","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T16:50:13Z","timestamp":1773679813000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Aquisinoids A and B: Two New Sesquiterpenoid\u2010Benzaldehyde Hybrids From\n                    <i>Aquilaria Sinensis<\/i>"],"prefix":"10.1002","volume":"23","author":[{"given":"Li\u2010Fen","family":"Ma","sequence":"first","affiliation":[{"name":"School of Pharmacy Guizhou Medical University  Guiyang People's Republic of China"},{"name":"Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences  Zhongshan People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Huang","sequence":"additional","affiliation":[{"name":"Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences  Zhongshan People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen\u2010Zhou","family":"Han","sequence":"additional","affiliation":[{"name":"Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences  Zhongshan People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9411-6358","authenticated-orcid":false,"given":"De\u2010an","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Pharmacy Guizhou Medical University  Guiyang People's Republic of China"},{"name":"Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences  Zhongshan People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9519-0372","authenticated-orcid":false,"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmacy Guizhou Medical University  Guiyang People's Republic of China"},{"name":"Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences  Zhongshan People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.4c06383"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1468393"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8RA09409H"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bse.2022.104413"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2024.105824"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.3c00372"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.2c00145"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2016.05.014"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2024.106143"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytol.2016.07.017"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27165350"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules30091984"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2015.08.009"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2025.114723"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2025.114477"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.5c00574"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1875-5364(24)60722-3"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2019.1576657"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2019.104301"}],"container-title":["Chemistry &amp; 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