{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T12:46:56Z","timestamp":1775998016283,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["20720220055"],"award-info":[{"award-number":["20720220055"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Diabetes is a complex and refractory metabolic disease severely threatening human health. A common feature of both type 1 and advanced type 2 diabetes is the failure and loss of functional \u03b2\u2010cells. Stimulating pancreatic \u03b2 cell proliferation for endogenous regeneration represents the most direct therapeutic approach.Through screening of secondary metabolites from the endophytic fungus of\n                    <jats:italic>Ajuga decumbens Thunb<\/jats:italic>\n                    using a zebrafish model, we identified\n                    <jats:bold>Arenarine D<\/jats:bold>\n                    promoting \u03b2 cell regeneration. In a low\u2010dose STZ\u2010induced T1DM mouse model,\n                    <jats:bold>Arenarine D<\/jats:bold>\n                    treatment lowered blood glucose and improved insulin resistance. Importantly, we found it promotes mouse \u03b2 cell proliferation by inhibiting DYRK1A. To our knowledge, we are the first to report that\n                    <jats:bold>Arenarine D<\/jats:bold>\n                    can promote the proliferation of pancreatic \u03b2 cells by inhibiting DYRK1A, and this effect stems from the replication of existing \u03b2 cells rather than other pathways. This demonstrates the great potential of\n                    <jats:bold>Arenarine D<\/jats:bold>\n                    in the treatment of T1DM.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71132","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T04:20:43Z","timestamp":1774326043000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Arenarine D Promotes Pancreatic \u03b2 Cell Proliferation Via DYRK1A Inhibition for T1DM Therapy"],"prefix":"10.1002","volume":"23","author":[{"given":"Chen","family":"Wang","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences Fujian Provincial Key Laboratory of Innovative Drug Target Research Xiamen University  Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Fujian Provincial Key Laboratory of Innovative Drug Target Research Xiamen University  Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7772-8935","authenticated-orcid":false,"given":"Shuo","family":"Gao","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Fujian Provincial Key Laboratory of Innovative Drug Target Research Xiamen University  Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Fujian Provincial Key Laboratory of Innovative Drug Target Research Xiamen University  Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Fujian Provincial Key Laboratory of Innovative Drug Target Research Xiamen University  Xiamen 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