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This study presents the first evaluation of the anti\u2010inflammatory and antinociceptive properties of the europium complex [Eu(dbm)\n                    <jats:sub>3<\/jats:sub>\n                    .LAP], derived from Lapachol, and investigates its possible interaction with the TRPA1 channel in adult zebrafish. The complex was administered intramuscularly, and its effects were compared with camphor and morphine controls. In vivo findings were integrated with in silico docking, molecular dynamics simulations, and predictive pharmacokinetic analysis. Eu(dbm)\n                    <jats:sub>3<\/jats:sub>\n                    .LAP (40\u00a0mg\/kg, oral) was effective specifically in the inflammatory phase, and its effect was blocked by camphor, indicating TRPA1 modulation. The compound also reduced carrageenan\u2010induced inflammation and attenuated oxidative stress in nerve and liver tissues. In silico predictions indicated high intestinal absorption (\u223c100%), good blood\u2013brain permeability (LogBB = 0.62), and low cardiotoxicity (pKi\n                    <jats:sub>hERG<\/jats:sub>\n                    = 7.73). Docking revealed a binding energy of \u22128.1 kcal\u00b7mol\n                    <jats:sup>\u2212<\/jats:sup>\n                    <jats:sup>1<\/jats:sup>\n                    with stable interactions involving LYS1046, TYR1049, and LYS1052. Molecular dynamics confirmed stability over 100\u00a0ns and preservation of key hydrogen bonds, supporting the modulatory potential observed in vivo.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71141","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T06:49:48Z","timestamp":1774507788000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Europium Metal Complex [Eu(dbm)\n                    <sub>3<\/sub>\n                    .LAP] Promotes Antinociceptive Behavior via TRPA1 Neuromodulation and an Anti\u2010Inflammatory Effect in Adult Zebrafish"],"prefix":"10.1002","volume":"23","author":[{"given":"Emanuela de Lima","family":"Rebou\u00e7as Borges","sequence":"first","affiliation":[{"name":"Biotechnology and Molecular Biology Laboratory, Health Sciences Center Itaperi Campus, State University of Cear\u00e1  Fortaleza Cear\u00e1 Brazil"},{"name":"Postgraduate Program in 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