{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T16:03:57Z","timestamp":1785341037086,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Two structurally new benzene derivatives, designated as Guignarphenyl A (\n                      <jats:bold>1<\/jats:bold>\n                      ) and Guignarphenyl B (\n                      <jats:bold>2<\/jats:bold>\n                      ), and one structurally unique meroterpenoid named Guignarpenoid A (\n                      <jats:bold>6<\/jats:bold>\n                      ) were successfully isolated and identified from the solid fermentation products of the endophytic fungus\n                      <jats:italic>Guignardia mangiferae<\/jats:italic>\n                      strain VDL166 (derived from\n                      <jats:italic>Vaccinium dunalianum<\/jats:italic>\n                      Wight, Ericaceae). Among these new compounds, compound\n                      <jats:bold>1<\/jats:bold>\n                      is reported for the first time in nature, while compounds\n                      <jats:bold>2<\/jats:bold>\n                      and\n                      <jats:bold>6<\/jats:bold>\n                      are newly identified analogs. Additionally, thirteen known secondary metabolites (\n                      <jats:bold>3<\/jats:bold>\n                      \u2013\n                      <jats:bold>5<\/jats:bold>\n                      ,\n                      <jats:bold>7<\/jats:bold>\n                      \u2013\n                      <jats:bold>16<\/jats:bold>\n                      ) were obtained. The structures of all compounds were elucidated by comprehensive nuclear magnetic resonance (NMR) spectroscopic analysis combined with\n                      <jats:bold>c<\/jats:bold>\n                      omputed\n                      <jats:sup>13<\/jats:sup>\n                      C NMR chemical shift analysis and DP4+ probability analysis for key relative configurations, and electronic circular dichroism (ECD) calculations. All isolates were evaluated for their in vitro antifungal activities against four phytopathogenic fungi (\n                      <jats:italic>Alternaria brassicicola<\/jats:italic>\n                      ,\n                      <jats:italic>Botrytis cinerea<\/jats:italic>\n                      ,\n                      <jats:italic>Phytophthora infestans<\/jats:italic>\n                      , and\n                      <jats:italic>Valsa mali<\/jats:italic>\n                      ). Among them, compound\n                      <jats:bold>6<\/jats:bold>\n                      exhibited the most potent and broad\u2010spectrum activity with MICs ranging from 12.5 to 25.0\u00a0\u00b5g\/mL, comparable to the positive controls (Carbendazim and Thiabendazole).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>\n                      <jats:list>\n                        <jats:list-item>\n                          <jats:p>\n                            Two new benzene derivatives, guignarphenyl A (\n                            <jats:bold>1<\/jats:bold>\n                            ) and guignarphenyl B (\n                            <jats:bold>2<\/jats:bold>\n                            ), and a novel meroterpenoid, guignarpenoid\n                            <jats:bold>A<\/jats:bold>\n                            (\n                            <jats:bold>6<\/jats:bold>\n                            ), were isolated from\n                            <jats:italic>Guignardia mangiferae<\/jats:italic>\n                            VDL166.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Structures were elucidated by NMR, ECD calculations, and DP4+ probability analysis.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            Compound\n                            <jats:bold>6<\/jats:bold>\n                            showed potent broad\u2010spectrum antifungal activity (MICs 12.5\u201325.0\u00a0\u00b5g\/mL).\n                          <\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>\n                            Bioactivity\u2010guided study confirms the antifungal potential of\n                            <jats:italic>G. mangiferae<\/jats:italic>\n                            metabolites.\n                          <\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cbdv.71150","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T16:16:06Z","timestamp":1775060166000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Two New Compounds Isolated From the Endophytic Fungus\n                    <i>Guignardia Mangiferae<\/i>\n                    VDL166 of\n                    <i>Vaccinium Dunalianum<\/i>"],"prefix":"10.1002","volume":"23","author":[{"given":"Jiao","family":"Yao","sequence":"first","affiliation":[{"name":"Key Laboratory of State Forestry Administration on Highly\u2010Efficient Utilization of Forestry Biomass Resources in Southwest China Southwest Forestry University  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling\u2010Feng","family":"He","sequence":"additional","affiliation":[{"name":"Key Laboratory of State Forestry Administration on Highly\u2010Efficient Utilization of Forestry Biomass Resources in Southwest China Southwest Forestry University  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng\u2010Yun","family":"Wei","sequence":"additional","affiliation":[{"name":"Key Laboratory of State Forestry Administration on Highly\u2010Efficient Utilization of Forestry Biomass Resources in Southwest China Southwest Forestry University  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of State Forestry Administration on Highly\u2010Efficient Utilization of Forestry Biomass Resources 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