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In this study, we aimed to investigate the chemical diversity and biological potential of the mangrove\u2010derived fungus\n                    <jats:italic>Cytospora rhizophorae<\/jats:italic>\n                    SCNU\u2010F0054, leading to the isolation of four new polyketides, namely (14\n                    <jats:italic>R<\/jats:italic>\n                    , 15'\n                    <jats:italic>R<\/jats:italic>\n                    )\u2010integracin D (\n                    <jats:bold>1<\/jats:bold>\n                    ), cytospyrone B (\n                    <jats:bold>8<\/jats:bold>\n                    ), furanone 2 (\n                    <jats:bold>12<\/jats:bold>\n                    ), 4\u2010ethyl\u20102\u2010hydroxy\u20102,5\u2010dimethylcyclopent\u20104\u2010ene\u20101,3\u2010dione (\n                    <jats:bold>14<\/jats:bold>\n                    ), together with ten known analogues. Their structures were elucidated based on extensive spectroscopic analyses, TDDFT\u2010ECD calculations, and comparisons of experimental ECD spectra. In antibacterial assays, compound\n                    <jats:bold>7<\/jats:bold>\n                    exhibited potent, broad\u2010spectrum activity against all tested strains, with MIC ranging from 1.56 to 6.25\n                    <jats:italic>\u00b5<\/jats:italic>\n                    g\/mL. Among the dimeric alkylresorcinols, the sulfated derivative\n                    <jats:bold>1<\/jats:bold>\n                    was most active against\n                    <jats:italic>S. aureus<\/jats:italic>\n                    and\n                    <jats:italic>E. coli<\/jats:italic>\n                    . In\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010glucosidase inhibitory assay, alkylresorcinols\n                    <jats:bold>1<\/jats:bold>\n                    ,\n                    <jats:bold>2<\/jats:bold>\n                    ,\n                    <jats:bold>4<\/jats:bold>\n                    , and\n                    <jats:bold>5<\/jats:bold>\n                    outperformed the positive control (1\u2010deoxynojirimycin), with IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 3.53\u221212.35\n                    <jats:italic>\u00b5<\/jats:italic>\n                    M. Overall, the alkylresorcinol subclass demonstrated stronger antibacterial and enzyme inhibitory activities than the other polyketides in this study, highlighting their potential as promising lead compounds for further pharmaceutical development.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71166","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T16:25:17Z","timestamp":1775060717000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bioactive Polyketides From the Mangrove Endophytic Fungus\n                    <i>Cytospora Rhizophorae<\/i>\n                    SCNU\u2010F0054"],"prefix":"10.1002","volume":"23","author":[{"given":"Zirong","family":"Lin","sequence":"first","affiliation":[{"name":"School of Chemistry South China Normal University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2949-7343","authenticated-orcid":false,"given":"Chunmei","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Chemistry South China Normal University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Chemistry South China Normal University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialin","family":"Li","sequence":"additional","affiliation":[{"name":"School of Chemistry South China Normal University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhua","family":"Long","sequence":"additional","affiliation":[{"name":"School of Chemistry South China Normal University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,1]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4RA11756E"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2022.114117"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1NP00041A"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/np100889v"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.5c00425"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.11646\/phytotaxa.669.1.3"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.funbio.2015.01.005"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2025.114704"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2022.113352"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25184224"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41429\u2010022\u201000591\u2010x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol101062f"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.8b04107"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo201755v"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2024.114344"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2021.112730"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2009.11.008"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/np970338f"},{"key":"e_1_2_9_20_1","unstructured":"G. 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