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The structures of\n                    <jats:bold>1<\/jats:bold>\n                    and\n                    <jats:bold>2<\/jats:bold>\n                    were elucidated by a combination analysis of HRESIMS, 1D and 2D NMR spectra, and their absolute configurations were determined by electronic circular dichroism (ECD) calculations. Villosarins A and B featured two unusual hydroquinone units modified by furan\u20102,5\u2010diones. Among the 10 isolates, compounds\n                    <jats:bold>1<\/jats:bold>\n                    ,\n                    <jats:bold>2<\/jats:bold>\n                    ,\n                    <jats:bold>7<\/jats:bold>\n                    \u2212\n                    <jats:bold>10<\/jats:bold>\n                    were evaluated for inhibitory activity on the production of inflammatory cytokines, interleukin\u20106 (IL\u20106), interleukin\u20101\n                    <jats:italic>\u03b2<\/jats:italic>\n                    (IL\u20101\n                    <jats:italic>\u03b2<\/jats:italic>\n                    ), and tumor necrosis factor\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    (TNF\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    ) in lipopolysaccharide (LPS)\u2010stimulated RAW 264.7 mouse macrophages. Villosarins A (\n                    <jats:bold>1<\/jats:bold>\n                    ) and B (\n                    <jats:bold>2<\/jats:bold>\n                    ) showed potent inhibitory activity on the production of IL\u20106, IL\u20101\n                    <jats:italic>\u03b2<\/jats:italic>\n                    , and TNF\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    in a dose\u2010dependent manner.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.71167","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T06:05:31Z","timestamp":1775801131000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Villosarins A and B, Anti\u2010Inflammatory Meroterpenoids From the Marine Sponge\n                    <i>Dysidea Villosa<\/i>"],"prefix":"10.1002","volume":"23","author":[{"given":"Fan\u2010Yu","family":"Bian","sequence":"first","affiliation":[{"name":"College of Food Sciences &amp; Technology Shanghai Ocean University, S  hanghai China"},{"name":"Research Center for Marine Drugs, State Key Laboratory of Microbial Metabolism, Department of Pharmacy Ren Ji Hospital, Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Zheng","sequence":"additional","affiliation":[{"name":"Research Center for Marine Drugs, State Key Laboratory of Microbial Metabolism, Department of Pharmacy Ren Ji Hospital, Shanghai Jiao Tong University  Shanghai China"},{"name":"School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang\u2010Chao","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Engineering, College of Chemical Engineering Northwest University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao\u2010Min","family":"Li","sequence":"additional","affiliation":[{"name":"Research Center for Marine Drugs, State Key Laboratory of Microbial Metabolism, Department of Pharmacy Ren Ji Hospital, Shanghai Jiao Tong University  Shanghai China"},{"name":"School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia\u2010Huan","family":"Wu","sequence":"additional","affiliation":[{"name":"Research Center for Marine Drugs, State Key Laboratory of Microbial Metabolism, Department of Pharmacy Ren Ji Hospital, Shanghai Jiao Tong University  Shanghai China"},{"name":"School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan\u2010Feng","family":"Deng","sequence":"additional","affiliation":[{"name":"Research Center for Marine Drugs, State Key Laboratory of Microbial Metabolism, Department of Pharmacy Ren Ji Hospital, Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4835-4775","authenticated-orcid":false,"given":"Hou\u2010Wen","family":"Lin","sequence":"additional","affiliation":[{"name":"College of Food Sciences &amp; 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